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Background <p>Airway clearance is essential in managing bronchiectasis, yet the benefit of inhaled hypertonic saline (HS) in non–cystic fibrosis (non-CF) disease remains unclear. While HS improves mucociliary clearance and clinical outcomes in cystic fibrosis, supporting evidence in non-CF bronchiectasis has been limited. With newly available trial data, this updated meta-analysis reassesses the efficacy of inhaled HS in adults with non-CF bronchiectasis.</p> Method <p>We systematically searched PubMed, Cochrane CENTRAL, and Embase for randomized controlled trials (RCTs) comparing inhaled HS with control group (Non-HS), either isotonic saline or standard of care, in adults with non-CF bronchiectasis. Outcomes included changes in forced expiratory volume in one second (FEV₁), forced vital capacity (FVC), and pulmonary exacerbation frequency within 52 weeks. The risk of bias was assessed with the Cochrane tool. A random-effects model was applied.</p> Results <p>Four RCTs involving 386 adults were included. Compared with Non-HS, HS did not significantly improve FEV₁ (SMD 0.03; 95% CI − 0.07 to 0.13; low certainty) or FVC (SMD 0.10; 95% CI − 0.06 to 0.25; low certainty), and pulmonary exacerbation rates (SMD − 0.02; 95% CI − 0.48 to 0.45; very low certainty).</p> Conclusion <p>In adults with non-CF bronchiectasis, inhaled HS offers no meaningful advantage over Non-HS for lung function or exacerbation reduction. Larger, high-quality RCTs are needed to identify potential benefits.</p>

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Hypertonic saline in non–cystic fibrosis bronchiectasis (Hyper-BRONCHI): an updated systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月12日

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  • Nhan Nguyen,
  • Yacin Zawam,
  • Nghi Bao Tran,
  • Nathalia Alves de Barros e Lyra,
  • Vinh Quang Tri Ho,
  • David Downes,
  • Vy Ngoc Dan Nguyen,
  • Ha Duc Thien Le,
  • Jafar Aljazeeri

摘要

Background

Airway clearance is essential in managing bronchiectasis, yet the benefit of inhaled hypertonic saline (HS) in non–cystic fibrosis (non-CF) disease remains unclear. While HS improves mucociliary clearance and clinical outcomes in cystic fibrosis, supporting evidence in non-CF bronchiectasis has been limited. With newly available trial data, this updated meta-analysis reassesses the efficacy of inhaled HS in adults with non-CF bronchiectasis.

Method

We systematically searched PubMed, Cochrane CENTRAL, and Embase for randomized controlled trials (RCTs) comparing inhaled HS with control group (Non-HS), either isotonic saline or standard of care, in adults with non-CF bronchiectasis. Outcomes included changes in forced expiratory volume in one second (FEV₁), forced vital capacity (FVC), and pulmonary exacerbation frequency within 52 weeks. The risk of bias was assessed with the Cochrane tool. A random-effects model was applied.

Results

Four RCTs involving 386 adults were included. Compared with Non-HS, HS did not significantly improve FEV₁ (SMD 0.03; 95% CI − 0.07 to 0.13; low certainty) or FVC (SMD 0.10; 95% CI − 0.06 to 0.25; low certainty), and pulmonary exacerbation rates (SMD − 0.02; 95% CI − 0.48 to 0.45; very low certainty).

Conclusion

In adults with non-CF bronchiectasis, inhaled HS offers no meaningful advantage over Non-HS for lung function or exacerbation reduction. Larger, high-quality RCTs are needed to identify potential benefits.