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Introduction <p>The impact of high altitude on patients with interstitial lung disease (ILD) remains unclear. This study aimed to describe the clinical characteristics of ILD patients in high-altitude regions.</p> Methods <p>This retrospective observational study included patients diagnosed with Idiopathic Pulmonary Fibrosis (IPF) and Connective Tissue Disease-associated ILD (CTD-ILD) hospitalized at two hospitals in Qinghai and Tibet between April 2018 and September 2021. Patients were categorized into high-altitude (≥ 2500&#xa0;m) and low-altitude (&lt; 2500&#xa0;m) groups. Demographic, clinical, hematological, and pulmonary function data were collected and analysed.</p> Results <p>A total of 119 patients were enrolled, with 56 in the high-altitude group and 63 in the low-altitude group. Compared with the low-altitude group, the high-altitude group had a significantly greater proportion of CTD-ILD patients (42.2% vs. 82.1%, <i>p</i> &lt; 0.001). Patients in the high-altitude group presented higher red blood cell counts and hemoglobin and hematocrit levels but lower PaO<sub>2</sub>/FiO<sub>2</sub> ratio (P/F ratio), FVC, and DLCO.</p> Conclusions <p>This study revealed a higher prevalence of CTD-ILD, an increased proportion of Tibetan ethnicity, differences in the P/F ratio, MCV, FVC, MCHC, and HGB levels in the high-altitude group.</p>

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Clinical characteristics of high-altitude interstitial lung disease: a two-center, retrospective, observational study

  • 期刊论文

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  • 发表日期：

    2026年1月21日

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  • Liang Zhou,
  • Min Zhu,
  • Ling Chen,
  • Yujun Wang,
  • Linrui Xu,
  • Jia Liu,
  • Lei Chen,
  • Yajun Tuo,
  • Qucuo Meilang,
  • Fengming Luo

摘要

Introduction

The impact of high altitude on patients with interstitial lung disease (ILD) remains unclear. This study aimed to describe the clinical characteristics of ILD patients in high-altitude regions.

Methods

This retrospective observational study included patients diagnosed with Idiopathic Pulmonary Fibrosis (IPF) and Connective Tissue Disease-associated ILD (CTD-ILD) hospitalized at two hospitals in Qinghai and Tibet between April 2018 and September 2021. Patients were categorized into high-altitude (≥ 2500 m) and low-altitude (< 2500 m) groups. Demographic, clinical, hematological, and pulmonary function data were collected and analysed.

Results

A total of 119 patients were enrolled, with 56 in the high-altitude group and 63 in the low-altitude group. Compared with the low-altitude group, the high-altitude group had a significantly greater proportion of CTD-ILD patients (42.2% vs. 82.1%, p < 0.001). Patients in the high-altitude group presented higher red blood cell counts and hemoglobin and hematocrit levels but lower PaO2/FiO2 ratio (P/F ratio), FVC, and DLCO.

Conclusions

This study revealed a higher prevalence of CTD-ILD, an increased proportion of Tibetan ethnicity, differences in the P/F ratio, MCV, FVC, MCHC, and HGB levels in the high-altitude group.