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Introduction <p>Parenchymal lung involvement occurs in &lt;10% of Hodgkin lymphoma and &lt;5% of non‑Hodgkin lymphoma, and its diagnosis during pregnancy is particularly challenging due to nonspecific symptoms that overlap with gestation and the potential fetal impact of diagnostic procedures. While tissue biopsy is essential, conventional minimally invasive techniques often yield insufficient samples, and surgical biopsy is more invasive that carries risks for the fetus. </p> Case presentation <p>We present the case of a pregnant woman with fever and pulmonary lesions. A multidisciplinary team employed transbronchial lung cryobiopsy under general anesthesia, which provided crucial clues for definitive diagnosis of Epstein-Barr virus positive cytotoxic T-cell lymphoma and enabled the initiation of timely treatment.</p> Conclusion <p>This case suggests that transbronchial lung cryobiopsy may be a potential feasible and relatively safe option for selected pregnant women with rapidly progressive and diagnostically challenging lung lesions. However, it should be performed in experienced centers under multidisciplinary team management and close monitoring. It underscores that necessary procedures should not be delayed due to pregnancy and highlights the critical role of individualized risk-benefit assessment in achieving a timely diagnosis and guiding management.</p>

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A 30-year-old pregnant woman with recurrent fever, pulmonary consolidation and halo sign: a case report

  • 期刊论文

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  • 发表日期：

    2026年1月18日

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  • Wanyu Niu,
  • Zhe Jin,
  • Chengli Que,
  • Wen Sun,
  • Guangfa Wang

摘要

Introduction

Parenchymal lung involvement occurs in <10% of Hodgkin lymphoma and <5% of non‑Hodgkin lymphoma, and its diagnosis during pregnancy is particularly challenging due to nonspecific symptoms that overlap with gestation and the potential fetal impact of diagnostic procedures. While tissue biopsy is essential, conventional minimally invasive techniques often yield insufficient samples, and surgical biopsy is more invasive that carries risks for the fetus.

Case presentation

We present the case of a pregnant woman with fever and pulmonary lesions. A multidisciplinary team employed transbronchial lung cryobiopsy under general anesthesia, which provided crucial clues for definitive diagnosis of Epstein-Barr virus positive cytotoxic T-cell lymphoma and enabled the initiation of timely treatment.

Conclusion

This case suggests that transbronchial lung cryobiopsy may be a potential feasible and relatively safe option for selected pregnant women with rapidly progressive and diagnostically challenging lung lesions. However, it should be performed in experienced centers under multidisciplinary team management and close monitoring. It underscores that necessary procedures should not be delayed due to pregnancy and highlights the critical role of individualized risk-benefit assessment in achieving a timely diagnosis and guiding management.