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Background <p>Chronic obstructive pulmonary disease (COPD) is a disease with a high socioeconomic burden for the global population. Identifying those individuals with a higher potential to develop the disease is essential for reducing its incidence.</p> Methods <p>This is an observational, longitudinal study that uses data from the 1978/1979 Ribeirão Preto City birth cohort (São Paulo State, Brazil). The study included 895 individuals who participated at the age of 23–25 and 37–38 years. Asthmatics were diagnosed by methacholine bronchial challenge test and were excluded from the analysis. A multiple linear regression was performed to evaluate the association of active smoking, passive smoking, body mass index (BMI), C-reactive protein (CRP) levels, and respiratory symptoms with FEV1 variation between ages.</p> Results <p>The analysis showed an association between BMI, CRP levels, and active smoking with FEV1 fall. Active smoking increased FEV1 decline by 1.95%. For each 1&#xa0;kg/m² increase in BMI, there was a 0.28% loss in FEV1, while an increase in CRP level of 1&#xa0;mg/dL was associated to a 0.76% additional FEV1 decline.</p> Conclusion <p>In addition to the well-known relationship between smoking and pulmonary function decline, there was also an association with BMI and CRP levels, suggesting the hypothesis that a metabolic process may contribute to the development of COPD.</p>

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Longitudinal study of the influence of obesity, C-reactive protein, and smoking on FEV1 decline in young adulthood

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • Ana Carolina Cunha,
  • Milton Faria-Jr,
  • Heloisa Bettiol,
  • Marco Antonio Barbieri,
  • Cecilia Claudia Costa Ribeiro,
  • Elcio Oliveira Vianna

摘要

Background

Chronic obstructive pulmonary disease (COPD) is a disease with a high socioeconomic burden for the global population. Identifying those individuals with a higher potential to develop the disease is essential for reducing its incidence.

Methods

This is an observational, longitudinal study that uses data from the 1978/1979 Ribeirão Preto City birth cohort (São Paulo State, Brazil). The study included 895 individuals who participated at the age of 23–25 and 37–38 years. Asthmatics were diagnosed by methacholine bronchial challenge test and were excluded from the analysis. A multiple linear regression was performed to evaluate the association of active smoking, passive smoking, body mass index (BMI), C-reactive protein (CRP) levels, and respiratory symptoms with FEV1 variation between ages.

Results

The analysis showed an association between BMI, CRP levels, and active smoking with FEV1 fall. Active smoking increased FEV1 decline by 1.95%. For each 1 kg/m² increase in BMI, there was a 0.28% loss in FEV1, while an increase in CRP level of 1 mg/dL was associated to a 0.76% additional FEV1 decline.

Conclusion

In addition to the well-known relationship between smoking and pulmonary function decline, there was also an association with BMI and CRP levels, suggesting the hypothesis that a metabolic process may contribute to the development of COPD.