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Background <p>Increasing evidence suggests that abdominal fat distribution is a greater predictor of metabolic risk (MetS) than BMI. This study aimed to evaluate the 10-year cardiometabolic consequences of isolated abdominal obesity (IAO) and its association with MetS and health-related quality of life (HRQoL).</p> Methods <p>This longitudinal cohort study included 552 adults from the Turkestan region of Kazakhstan who underwent baseline assessment in 2014 and follow-up examination in 2024. Anthropometric, clinical, and laboratory parameters were measured, and the HRQoL was assessed by the SF-36 questionnaire.</p> Results <p>At baseline, 403 participants (73%) had IAO, and 149 (27%) did not. Participants with IAO were older (45 vs. 37 years, <i>p</i> &lt; 0.001) and more frequently female (79%). They had higher body weight, waist circumference, BMI, blood pressure, and unfavorable metabolic parameters, including higher cholesterol, triglyceride, and glucose levels (all <i>p</i> &lt; 0.05). Metabolic syndrome was more prevalent in the IAO group (30% vs. 1%, <i>p</i> &lt; 0.001). After 10 years, IAO was observed in 472 participants: 97% of those with IAO at baseline remained obese, compared with 54% of those without baseline obesity who developed it (<i>p</i> &lt; 0.001). Baseline IAO independently predicted incident metabolic syndrome (OR<sub>adj</sub> = 1.34; <i>p</i> = 0.041). Participants with persistent IAO had lower HRQoL scores in physical functioning, general health, and mental health than individuals without IAO (<i>p</i> &lt; 0.05).</p> Conclusions <p>Persistent isolated abdominal obesity was associated with lower health-related quality of life and independently predicted metabolic syndrome over the 10-year follow-up period. These results highlight the importance of assessing abdominal adiposity in clinical practice.</p>

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Ten-year cardiometabolic progression and health-related quality of life in individuals with isolated abdominal obesity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月20日

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  • Lazzat Nazarova,
  • Gulnaz Nuskabayeva,
  • Galiya Assanova,
  • Magzhan Tilemissov,
  • Gulmira Izzatullayeva,
  • Dilbar Aidarbekova,
  • Karlygash Sadykova,
  • Yerbolat Saruarov

摘要

Background

Increasing evidence suggests that abdominal fat distribution is a greater predictor of metabolic risk (MetS) than BMI. This study aimed to evaluate the 10-year cardiometabolic consequences of isolated abdominal obesity (IAO) and its association with MetS and health-related quality of life (HRQoL).

Methods

This longitudinal cohort study included 552 adults from the Turkestan region of Kazakhstan who underwent baseline assessment in 2014 and follow-up examination in 2024. Anthropometric, clinical, and laboratory parameters were measured, and the HRQoL was assessed by the SF-36 questionnaire.

Results

At baseline, 403 participants (73%) had IAO, and 149 (27%) did not. Participants with IAO were older (45 vs. 37 years, p < 0.001) and more frequently female (79%). They had higher body weight, waist circumference, BMI, blood pressure, and unfavorable metabolic parameters, including higher cholesterol, triglyceride, and glucose levels (all p < 0.05). Metabolic syndrome was more prevalent in the IAO group (30% vs. 1%, p < 0.001). After 10 years, IAO was observed in 472 participants: 97% of those with IAO at baseline remained obese, compared with 54% of those without baseline obesity who developed it (p < 0.001). Baseline IAO independently predicted incident metabolic syndrome (ORadj = 1.34; p = 0.041). Participants with persistent IAO had lower HRQoL scores in physical functioning, general health, and mental health than individuals without IAO (p < 0.05).

Conclusions

Persistent isolated abdominal obesity was associated with lower health-related quality of life and independently predicted metabolic syndrome over the 10-year follow-up period. These results highlight the importance of assessing abdominal adiposity in clinical practice.