Scholarlink

Background <p>NVX-CoV2373 is a nanoparticle, protein-based COVID-19 vaccine. Individuals who are immunocompromised (IIC) are at high risk for infection and severe disease; however, real-world NVX-CoV2373 impact data in IIC are limited.</p> Methods <p>The objective of this study was to assess whether NVX-CoV2373 reduced the risk of SARS-CoV-2 infection and severe disease in IIC, compared to non-immunocompromised (non-IC) individuals. South Korean IIC aged ≥12 years who received a primary series, third dose, or fourth dose of NVX-CoV2373 were identified in The Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service (K-COV-N) database. IIC were propensity score matched to non-IC individuals to minimize potential confounding. Outcomes were any and severe SARS-CoV-2 infections, collected in cumulative 30-day risk windows through 180 days post vaccination in primary series and third- and fourth-dose groups. Adjusted hazard ratios (aHRs) measured relative vaccine impact by comparing outcomes between IIC and non-IC individuals across dose groups, overall, and by immunocompromising condition.</p> Results <p>A total of 755,727 doses of NVX-CoV2373 were administered from February–December 2022, with 400,435 IIC individuals included in this analysis. Through 180 days, aHRs (95% CI) for any SARS-CoV-2 infection were 1.10 (1.06–1.14), 1.05 (1.01–1.09), and 1.03 (1.02–1.05) for the primary series, third-dose, and fourth-dose groups; severe infection: 0.76 (0.52–1.12), 0.90 (0.53–1.51), and 1.11 (0.87–1.41), respectively. Risk estimates for any infection were relatively consistent across risk windows and among most immunocompromising conditions.</p> Conclusion <p>A similar risk of medically attended SARS-CoV-2 infection between IIC and non-IC was observed with both a homologous primary series and homologous or heterologous third and fourth doses of NVX-CoV2373, as well as across a variety of immunocompromising conditions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Real-world impact of NVX-CoV2373 COVID-19 vaccine in immunocompromised individuals in South Korea

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月12日

查看全文
  • Eunseon Gwak,
  • Seung-Ah Choe,
  • Kyuwon Kim,
  • Erdenetuya Bolormaa,
  • Manuela H. Gschwend,
  • Jonathan Fix,
  • Muruga Vadivale,
  • Matthew D. Rousculp,
  • Young June Choe

摘要

Background

NVX-CoV2373 is a nanoparticle, protein-based COVID-19 vaccine. Individuals who are immunocompromised (IIC) are at high risk for infection and severe disease; however, real-world NVX-CoV2373 impact data in IIC are limited.

Methods

The objective of this study was to assess whether NVX-CoV2373 reduced the risk of SARS-CoV-2 infection and severe disease in IIC, compared to non-immunocompromised (non-IC) individuals. South Korean IIC aged ≥12 years who received a primary series, third dose, or fourth dose of NVX-CoV2373 were identified in The Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service (K-COV-N) database. IIC were propensity score matched to non-IC individuals to minimize potential confounding. Outcomes were any and severe SARS-CoV-2 infections, collected in cumulative 30-day risk windows through 180 days post vaccination in primary series and third- and fourth-dose groups. Adjusted hazard ratios (aHRs) measured relative vaccine impact by comparing outcomes between IIC and non-IC individuals across dose groups, overall, and by immunocompromising condition.

Results

A total of 755,727 doses of NVX-CoV2373 were administered from February–December 2022, with 400,435 IIC individuals included in this analysis. Through 180 days, aHRs (95% CI) for any SARS-CoV-2 infection were 1.10 (1.06–1.14), 1.05 (1.01–1.09), and 1.03 (1.02–1.05) for the primary series, third-dose, and fourth-dose groups; severe infection: 0.76 (0.52–1.12), 0.90 (0.53–1.51), and 1.11 (0.87–1.41), respectively. Risk estimates for any infection were relatively consistent across risk windows and among most immunocompromising conditions.

Conclusion

A similar risk of medically attended SARS-CoV-2 infection between IIC and non-IC was observed with both a homologous primary series and homologous or heterologous third and fourth doses of NVX-CoV2373, as well as across a variety of immunocompromising conditions.