Scholarlink

Background <p>Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood.</p> Methods <p>Based on the China Kadoorie Biobank, a prospective cohort between 2004–2008 covering 5 urban and 5 rural areas, we included 138,764 males and 194,159 females aged 35 ~ 70 years. Weight change was defined as the difference between directly measured weight at baseline and self-reported weight at age 25. Incident COPD events were followed-up until the end of 2018. Cox proportional hazard models were conducted to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of adulthood weight change and early adulthood body mass index (BMI) with COPD risk.</p> Results <p>During a mean follow-up of 11.9 years, 3,732 and 3,154 incident COPD events occurred in males and females, respectively. In males, weight change and early adulthood BMI were inversely associated with COPD risk, while early adulthood obesity (BMI ≥ 28.0 kg/m<sup>2</sup>) was associated with an increased risk of COPD (HR = 1.76; 95% CI: 1.01, 3.08), compared with the 18.5 ~ 23.9 kg/m<sup>2</sup> early adulthood BMI group, among non-current smokers. In females, extreme weight loss and gain were associated with increased COPD risk. The effects of weight loss and gain on COPD were enhanced in the underweight and obese population, respectively, in early adulthood.</p> Conclusions <p>Weight change and early adulthood BMI were inversely linked to COPD risk in males, while in females, both extreme weight loss or gain increased COPD risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月22日

查看全文
  • Lu Chen,
  • Wei Yu,
  • Dianjianyi Sun,
  • Pei Pei,
  • Ling Yang,
  • Yiping Chen,
  • Huaidong Du,
  • Xujun Yang,
  • Maxim Barnard,
  • Junshi Chen,
  • Zhengming Chen,
  • Jun Lv,
  • Liming Li,
  • Canqing Yu,
  • Robert Clarke,
  • Rory Collins,
  • Richard Peto,
  • Robin Walters,
  • Daniel Avery,
  • Derrick Bennett,
  • Ruth Boxall,
  • Jonathan Clarke,
  • Ahmed Edris Mohamed,
  • Hannah Fry,
  • Yani Huang,
  • Pek Kei Im,
  • Andri Iona,
  • Christiana Kartsonaki,
  • Kshitij Kolhe,
  • Hubert Lam,
  • Kuang Lin,
  • James Liu,
  • Iona Millwood,
  • Sam Morris,
  • Qunhua Nie,
  • Alfred Pozarickij,
  • Maryam Rahmati,
  • Paul Ryder,
  • Maruf Sarder,
  • Dan Schmidt,
  • Becky Stevens,
  • Baihan Wang,
  • Lin Wang,
  • Neil Wright,
  • Xiaoming Yang,
  • Pang Yao,
  • Xiao Han,
  • Can Hou,
  • Qingmei Xia,
  • Chao Liu,
  • Lang Pan,
  • Zengchang Pang,
  • Ruqin Gao,
  • Shanpeng Li,
  • Haiping Duan,
  • Shaojie Wang,
  • Yongmei Liu,
  • Ranran Du,
  • Yajing Zang,
  • Liang Cheng,
  • Xiaocao Tian,
  • Hua Zhang,
  • Yaoming Zhai,
  • Feng Ning,
  • Xiaohui Sun,
  • Feifei Li,
  • Silu Lv,
  • Junzheng Wang,
  • Wei Hou,
  • Wei Sun,
  • Shichun Yan,
  • Xiaoming Cui,
  • Chi Wang,
  • Zhenyuan Wu,
  • Yanjie Li,
  • Quan Kang,
  • Huiming Luo,
  • Tingting Ou,
  • Xiangyang Zheng,
  • Zhendong Guo,
  • Shukuan Wu,
  • Yilei Li,
  • Huimei Li,
  • Ming Wu,
  • Yonglin Zhou,
  • Jinyi Zhou,
  • Ran Tao,
  • Jie Yang,
  • Jian Su,
  • Fang Liu,
  • Jun Zhang,
  • Yihe Hu,
  • Yan Lu,
  • Liangcai Ma,
  • Aiyu Tang,
  • Shuo Zhang,
  • Jianrong Jin,
  • Jingchao Liu,
  • Mei Lin,
  • Zhenzhen Lu,
  • Lifang Zhou,
  • Changping Xie,
  • Jian Lan,
  • Tingping Zhu,
  • Yun Liu,
  • Liuping Wei,
  • Liyuan Zhou,
  • Ningyu Chen,
  • Yulu Qin,
  • Sisi Wang,
  • Xianping Wu,
  • Ningmei Zhang,
  • Xiaofang Chen,
  • Xiaoyu Chang,
  • Mingqiang Yuan,
  • Xia Wu,
  • Wei Jiang,
  • Jiaqiu Liu,
  • Qiang Sun,
  • Faqing Chen,
  • Xiaolan Ren,
  • Caixia Dong,
  • Hui Zhang,
  • Enke Mao,
  • Xiaoping Wang,
  • Tao Wang,
  • Xi zhang,
  • Kai Kang,
  • Shixian Feng,
  • Huizi Tian,
  • Lei Fan,
  • XiaoLin Li,
  • Huarong Sun,
  • Pan He,
  • Xukui Zhang,
  • Min Yu,
  • Ruying Hu,
  • Hao Wang,
  • Xiaoyi Zhang,
  • Yuan Cao,
  • Kaixu Xie,
  • Lingli Chen,
  • Dun Shen,
  • Xiaojun Li,
  • Donghui Jin,
  • Li Yin,
  • Huilin Liu,
  • Zhongxi Fu,
  • Xin Xu,
  • Hao Zhang,
  • Jianwei Chen,
  • Yuan Peng,
  • Libo Zhang,
  • Chan Qu

摘要

Background

Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood.

Methods

Based on the China Kadoorie Biobank, a prospective cohort between 2004–2008 covering 5 urban and 5 rural areas, we included 138,764 males and 194,159 females aged 35 ~ 70 years. Weight change was defined as the difference between directly measured weight at baseline and self-reported weight at age 25. Incident COPD events were followed-up until the end of 2018. Cox proportional hazard models were conducted to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of adulthood weight change and early adulthood body mass index (BMI) with COPD risk.

Results

During a mean follow-up of 11.9 years, 3,732 and 3,154 incident COPD events occurred in males and females, respectively. In males, weight change and early adulthood BMI were inversely associated with COPD risk, while early adulthood obesity (BMI ≥ 28.0 kg/m2) was associated with an increased risk of COPD (HR = 1.76; 95% CI: 1.01, 3.08), compared with the 18.5 ~ 23.9 kg/m2 early adulthood BMI group, among non-current smokers. In females, extreme weight loss and gain were associated with increased COPD risk. The effects of weight loss and gain on COPD were enhanced in the underweight and obese population, respectively, in early adulthood.

Conclusions

Weight change and early adulthood BMI were inversely linked to COPD risk in males, while in females, both extreme weight loss or gain increased COPD risk.