Background <p>The prevalence of hyperuricemia is rising among oilfield workers in China. This study aimed to explore the underlying mechanisms between skipping breakfast and serum uric acid.</p> Methods <p>A total of 21,676 participants aged 20-60 from a large oilfield company in China were included. Association analysis, multivariate logistic, subgroup analysis, and moderated mediation analysis were performed to assess the association between skipping breakfast and hyperuricemia.</p> Results <p>We found that 24.48% of oilfield employees had hyperuricemia. The odds ratio of hyperuricemia linked to skipping breakfast was 0.78 (95%CI: 0.69-0.88). The association between skipping breakfast and hyperuricemia was mediated by TC (22.32%) and LDL-C (21.57%). Age moderated this mediation, with significant effects for skipping breakfast (<i>ß</i>: 0.553, 95%CI: 0.042-1.063) and TC (<i>ß</i>: -0.339, 95%CI: -0.586- -0.093). Similar results were observed for LDL-C mediation (<i>ß</i>: 0.522, 95%CI: 0.009-1.035; <i>ß</i>: -0.585, 95%CI: -0.894- -0.276).</p> Conclusion <p>Skipping breakfast positively influenced hyperuricemia through TC and LDL-C. Age moderated the relationship between skipping breakfast and serum uric acid. Greater attention should be given to young employees in Chinese oilfield enterprises, with dietary interventions implemented to reduce abnormal lipids metabolism and hyperuricemia.</p>