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Background <p>Osteoporotic fractures frequently occur in conjunction with various diseases, and the comorbidity of fractures is a significant contributor to their high disability and mortality rates. This study aimed to examine the pattern of comorbidity in fracture patients and non-fracture individuals.</p> Methods <p>Using data from community- and hospital-based populations in Jilin, China, we identified osteoporotic fracture patients over 40 years of age. We matched each fracture patient with two non-fracture individuals based on age (± 3 years) and sex. Major comorbidities including hypertension, type 2 diabetes, hyperlipidemia, obesity, coronary heart disease (CHD), stroke, hyperthyroidism, hyperparathyroidism, osteoporosis, rheumatoid arthritis, respiratory diseases, gastrointestinal diseases, and breast cancer, were ascrertained from patients’ laboratory test results and self-reported data.</p> Results <p>We identified 51 hospital-based fracture patients, 181 community-based fracture patients and 362 matched non-fracture individuals. The mean age for both overall fracture patients and non-fracture individuals was 67.8 years. Females accounted for 72.8% of overall fracture patients and 71.8% of non-fracture individuals. The most common comorbidity was hypertension for overall fracture patients (45.3%), hospital-based fracture patients (39.2%), and non-fracture individuals (56.4%), whereas hyperlipidemia was the most frequent condition for community-based fracture patients (63.6%). The top binary comorbidity combination pattern for community-based fracture patients (30.4%) and non-fracture individuals (29.6%) was hyperlipidemia &amp; hypertension, while for hospital-based (15.7%) and overall (15.1%) fracture patients it was hypertension &amp; type 2 diabetes. The average degree of comorbidity network for overall fracture patients (7.0) was higher than that for non-fracture individuals (5.4).</p> Conclusions <p>The most common comorbidities were hyperlipidemia and hypertension among fracture patients. As compared to non-fracture individuals, fracture patients exhibited a more complex comorbidity network. These findings help us better target the management of comorbidities in patients with osteoporotic fractures and reduce the burden associated with fractures.</p> Trial registration <p>Not applicable.</p>

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Top comorbidities in osteoporotic fracture patients in a northeast population in China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月2日

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  • Linghua Yang,
  • Ziyu Dong,
  • Baoming Yuan,
  • Jie Lei,
  • Juan Zhang,
  • Xiaohua Zhang,
  • Xinyan Shi,
  • Ann M. Vuong,
  • Shuman Yang

摘要

Background

Osteoporotic fractures frequently occur in conjunction with various diseases, and the comorbidity of fractures is a significant contributor to their high disability and mortality rates. This study aimed to examine the pattern of comorbidity in fracture patients and non-fracture individuals.

Methods

Using data from community- and hospital-based populations in Jilin, China, we identified osteoporotic fracture patients over 40 years of age. We matched each fracture patient with two non-fracture individuals based on age (± 3 years) and sex. Major comorbidities including hypertension, type 2 diabetes, hyperlipidemia, obesity, coronary heart disease (CHD), stroke, hyperthyroidism, hyperparathyroidism, osteoporosis, rheumatoid arthritis, respiratory diseases, gastrointestinal diseases, and breast cancer, were ascrertained from patients’ laboratory test results and self-reported data.

Results

We identified 51 hospital-based fracture patients, 181 community-based fracture patients and 362 matched non-fracture individuals. The mean age for both overall fracture patients and non-fracture individuals was 67.8 years. Females accounted for 72.8% of overall fracture patients and 71.8% of non-fracture individuals. The most common comorbidity was hypertension for overall fracture patients (45.3%), hospital-based fracture patients (39.2%), and non-fracture individuals (56.4%), whereas hyperlipidemia was the most frequent condition for community-based fracture patients (63.6%). The top binary comorbidity combination pattern for community-based fracture patients (30.4%) and non-fracture individuals (29.6%) was hyperlipidemia & hypertension, while for hospital-based (15.7%) and overall (15.1%) fracture patients it was hypertension & type 2 diabetes. The average degree of comorbidity network for overall fracture patients (7.0) was higher than that for non-fracture individuals (5.4).

Conclusions

The most common comorbidities were hyperlipidemia and hypertension among fracture patients. As compared to non-fracture individuals, fracture patients exhibited a more complex comorbidity network. These findings help us better target the management of comorbidities in patients with osteoporotic fractures and reduce the burden associated with fractures.

Trial registration

Not applicable.