Background <p>The burden of pregnancy loss remains high in low- and middle-income countries like Pakistan. The Every Newborn Action Plan (ENAP) aims to decrease the stillbirth rate to 12 per 1000 total births by 2030, in every country. Current estimates indicate that Pakistan is unlikely to achieve this ENAP target, as the stillbirth rate stands at 30.6 per 1000 total births.</p> Methods <p>This study used the 2019 Pakistan Maternal Mortality Survey to identify the community-level, sociodemographic, maternal, environmental, and health services factors that are associated with pregnancy loss. Due to characteristic differences in urban and rural communities, separate analyses were carried out for ever-married women of 15 to 49 years. Mixed effects negative binomial regression was used to analyze the urban (<i>n</i> = 5,887) and rural (<i>n</i> = 7,136) samples of women who reported at least one pregnancy.</p> Results <p>The separate analyses found the factors associated with pregnancy loss to vary between urban and rural areas. In urban areas, pregnancy loss was associated with maternal education, maternal age, current marital status, and sanitation facility type. In rural areas, pregnancy loss was associated with region of residence, wealth index, maternal age, current marital status, drinking water source, cooking fuel type, and sanitation facility type.</p> Conclusion <p>This study carries significant implications for alleviating the burden of pregnancy loss in Pakistan, in line with ENAP objectives. The separate analyses provide a novel perspective regarding the factors influencing pregnancy loss in urban and rural areas, allowing for targeted interventions.</p>