Background <p>Common mental disorders (CMDs) are highly prevalent in workplace settings, and have become a significant public health challenge. This study aims to assess the effectiveness of PRATICA^dr, a web application facilitated by a Return-to-Work Coordinator (RTW-C), with a focus on reducing sick leave duration and preventing relapse in individuals with CMDs.</p> Methods <p>PRATICA^dr, designed to enhance collaboration among Return-to-Work (RTW) stakeholders and provide systematic support throughout the RTW process, was evaluated in a quasi-experimental study. Survival analyses were used to compare sick leave durations and relapses between the experimental group (PRATICA^dr with RTW-C), and control groups (RTW-C only). Both conditions had equal distribution of 50% from large public health organizations (<i>n</i> = 35) and 50% from a large private financial organization (<i>n</i> = 35). Mixed linear models were used to observe changes in clinical symptoms over time, especially for the experimental group.</p> Results <p>The experimental group demonstrated significantly shorter sick leave durations and fewer relapses compared to the control group. Notably, the average absence duration was close to 3 months shorter in the experimental group. This difference was found when the RTW-C intervention (rehabilitation care) began 2 months after the onset of sick leave. Relapses occurred only in the control group (13.2%). The absence of relapses in the experimental group is noteworthy, along with the significant decrease in depressive and anxious symptoms over time.</p> Conclusions <p>The findings suggest that incorporating PRATICA^dr into RTW-C intervention can lead to substantial cost savings by facilitating coordination among stakeholders and guiding the RTW process with validated tools. Initiation of RTW-C intervention alongside PRATICA^dr within the first month of absence is recommended for optimal health and work outcomes.</p>