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Background <p>Although the dietary inflammatory index (DII) plays a vital role in human health, the association between the DII and women’s menopausal status is still unclear. The aim of this study was to investigate the associations of the energy-adjusted DII (E-DII) with natural menopause and hysterectomy among women aged 20–65 years in the National Health and Nutrition Examination Survey (NHANES).</p> Methods <p>We conducted a cross-sectional study to assess the associations of the E-DII with natural menopause and hysterectomy using multivariate regression models. To further explore the effect of the E-DII on early natural menopause, subgroup analyses were performed. Additionally, the correlations between the E-DII score and age at menopause or hysterectomy were evaluated via Spearman correlation analysis.</p> Results <p>Data from 9469 women were included in this study. After full adjustment, we observed a positive association between the E-DII and early natural menopause. The odds ratios (ORs) for quartile 4 and quartile 1 were 1.552 (95% CI: 1.043, 2.309) and 1.328 (0.767, 2.301), respectively. We also found positive evidence that the E-DII was associated with hysterectomy. The OR was 1.487 (1.069, 2.069) in quartile 3 versus quartile 1 and 1.729 (1.198, 2.497) for quartile 4 versus quartile 1. The correlation coefficients of the E-DII between the ages of menopause and hysterectomy patients were − 0.12 and − 0.11, respectively.</p> Conclusions <p>Our findings suggest that a higher E-DII strongly influences early natural menopause and hysterectomy, likely leading to their earlier onset. However, longitudinal studies or randomized clinical trials are necessary to further confirm our findings.</p>

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Associations between dietary inflammatory index with menopause and hysterectomy: findings from a national health and nutrition examination survey

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月15日

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  • Yi Guo,
  • Qiuyu Cao,
  • Shiya Huang,
  • Janbin Pi,
  • Wenyu Jia,
  • Yuzhuo Zhang,
  • Kunyin Li,
  • Yin Li,
  • Jintu Guan

摘要

Background

Although the dietary inflammatory index (DII) plays a vital role in human health, the association between the DII and women’s menopausal status is still unclear. The aim of this study was to investigate the associations of the energy-adjusted DII (E-DII) with natural menopause and hysterectomy among women aged 20–65 years in the National Health and Nutrition Examination Survey (NHANES).

Methods

We conducted a cross-sectional study to assess the associations of the E-DII with natural menopause and hysterectomy using multivariate regression models. To further explore the effect of the E-DII on early natural menopause, subgroup analyses were performed. Additionally, the correlations between the E-DII score and age at menopause or hysterectomy were evaluated via Spearman correlation analysis.

Results

Data from 9469 women were included in this study. After full adjustment, we observed a positive association between the E-DII and early natural menopause. The odds ratios (ORs) for quartile 4 and quartile 1 were 1.552 (95% CI: 1.043, 2.309) and 1.328 (0.767, 2.301), respectively. We also found positive evidence that the E-DII was associated with hysterectomy. The OR was 1.487 (1.069, 2.069) in quartile 3 versus quartile 1 and 1.729 (1.198, 2.497) for quartile 4 versus quartile 1. The correlation coefficients of the E-DII between the ages of menopause and hysterectomy patients were − 0.12 and − 0.11, respectively.

Conclusions

Our findings suggest that a higher E-DII strongly influences early natural menopause and hysterectomy, likely leading to their earlier onset. However, longitudinal studies or randomized clinical trials are necessary to further confirm our findings.