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Background <p>Neck pain is a significant public health issue, especially among office workers, with a prevalence ranging from 42 to 68%. This study aimed to evaluate the cost-utility and cost-benefit of a multi-component intervention targeting neck pain in the general population of office workers in Switzerland. The 12-week multi-component intervention consisted of neck exercises, health promotion information workshops, and workplace ergonomics sessions.</p> Methods <p>The study was designed as a stepped-wedge cluster randomized controlled trial and assessed using an employer’s perspective. The main analysis focused on the immediate post-intervention period. Long-term effects were examined in a subsample at the 4, 8, and 12-month follow-ups. The intervention effects on costs and quality-adjusted life years (QALYs) were estimated using generalized linear mixed-effects models, controlling for confounding factors. Incremental cost-effectiveness ratios (ICERs) and cost-effectiveness acceptability curves were presented, along with calculations of the break-even point and the return on investment. Various sensitivity analyses were performed.</p> Results <p>A total of 120 office workers participated in the trial, with 100 completing the intervention period and 94 completing the entire study. The main analysis included 392 observations. The intervention had a significant positive effect on QALYs and a nonsignificant effect on costs. The ICER was estimated at -25,325 per QALY gain, and the probability of the intervention being cost saving was estimated at 88%. The break-even point was reached one week after the end of the intervention.</p> Conclusion <p>The multi-component intervention is likely to reduce company costs and simultaneously improve the quality of life of employees. However, the implementation of such interventions critically depends on evidence of their cost-effectiveness. As there is still a large research gap in this area, future studies are needed.</p> Trial registration <p>ClinicalTrials.gov, <a href="https://clinicaltrials.gov/ct2/show/NCT04169646">NCT04169646</a>. Registered 15 November 2019-Retrospectively registered.</p> Trial protocol <p>Aegerter AM, Deforth M, Johnston V, Ernst MJ, Volken T, Luomajoki H, et al. On-site multi-component intervention to improve productivity and reduce the economic and personal burden of neck pain in Swiss office-workers (NEXpro): protocol for a cluster-randomized controlled trial. BMC Musculoskelet Disord. 2020;21(1):391.&#xa0;<a href="https://doi.org/10.1186/s12891-020-03388-x">https://doi.org/10.1186/s12891-020-03388-x</a>.</p>

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Cost-utility and cost–benefit analysis of a multi-component intervention (NEXpro) for neck-related symptoms in Swiss office workers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月15日

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  • Beatrice Brunner,
  • Andrea Martina Aegerter,
  • Venerina Johnston,
  • Thomas Volken,
  • Manja Deforth,
  • Gisela Sjøgaard,
  • Achim Elfering,
  • Markus Melloh,
  • Marco Barbero,
  • Jon Cornwall,
  • Yara Da Cruz Pereira,
  • Oliver Distler,
  • Julia Dratva,
  • Holger Dressel,
  • Tobias Egli,
  • Markus J. Ernst,
  • Irene Etzer-Hofer,
  • Deborah Falla,
  • Michelle Gisler,
  • Michelle Haas,
  • Sandro Klaus,
  • Gina M. Kobelt,
  • Kerstin Lüdtke,
  • Hannu Luomajoki,
  • Corinne Nicoletti,
  • Seraina Niggli,
  • Achim Nüssle,
  • Salome Richard,
  • Nadine Sax,
  • Katja Schülke,
  • Lukas Staub,
  • Thomas Zweig

摘要

Background

Neck pain is a significant public health issue, especially among office workers, with a prevalence ranging from 42 to 68%. This study aimed to evaluate the cost-utility and cost-benefit of a multi-component intervention targeting neck pain in the general population of office workers in Switzerland. The 12-week multi-component intervention consisted of neck exercises, health promotion information workshops, and workplace ergonomics sessions.

Methods

The study was designed as a stepped-wedge cluster randomized controlled trial and assessed using an employer’s perspective. The main analysis focused on the immediate post-intervention period. Long-term effects were examined in a subsample at the 4, 8, and 12-month follow-ups. The intervention effects on costs and quality-adjusted life years (QALYs) were estimated using generalized linear mixed-effects models, controlling for confounding factors. Incremental cost-effectiveness ratios (ICERs) and cost-effectiveness acceptability curves were presented, along with calculations of the break-even point and the return on investment. Various sensitivity analyses were performed.

Results

A total of 120 office workers participated in the trial, with 100 completing the intervention period and 94 completing the entire study. The main analysis included 392 observations. The intervention had a significant positive effect on QALYs and a nonsignificant effect on costs. The ICER was estimated at -25,325 per QALY gain, and the probability of the intervention being cost saving was estimated at 88%. The break-even point was reached one week after the end of the intervention.

Conclusion

The multi-component intervention is likely to reduce company costs and simultaneously improve the quality of life of employees. However, the implementation of such interventions critically depends on evidence of their cost-effectiveness. As there is still a large research gap in this area, future studies are needed.

Trial registration

ClinicalTrials.gov, NCT04169646. Registered 15 November 2019-Retrospectively registered.

Trial protocol

Aegerter AM, Deforth M, Johnston V, Ernst MJ, Volken T, Luomajoki H, et al. On-site multi-component intervention to improve productivity and reduce the economic and personal burden of neck pain in Swiss office-workers (NEXpro): protocol for a cluster-randomized controlled trial. BMC Musculoskelet Disord. 2020;21(1):391. https://doi.org/10.1186/s12891-020-03388-x.