HIV incidence and its associated factors among young adults with multiple sexual partners in Maputo, Mozambique: a vaccine preparedness study

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2024年10月2日

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Ivalda Macicame,
Nilesh Bhatt,
Edna Viegas,
Adam Yates,
Chiaka Nwoga,
Raquel Matavele Chissumba,
Vanessa Monteiro,
Michelle Imbach,
Mark Milazzo,
Qun Li,
Steven Schech,
Tsedal Mebrahtu,
Leigh Anne Eller,
Edith Swann,
Nelson L. Michael,
Merlin L. Robb,
Trevor A. Crowell,
Christina S. Polyak,
Ilesh Jani,
Julie Ake,
Khelvon Leonel Jose De Araujo,
Igor Capitine,
Lígia Chambule,
Celso Castino,
Eduardo Namalango,
Mirna Mutombene,
Maria Enosse,
Victoria Cumbane,
Felisberto Facuna,
Zebiba Hassen,
Luis Inhambizo,
Paulo Macamo,
Ferrao Mandlate,
José Manjate,
Carmélia Massingue,
Ana Mutola,
Patrícia Ramgi,
Gail Smith

摘要

Introduction

Sub-Saharan Africa has a high burden of HIV, particularly among female sex workers (FSW) and men who have sex with men (MSM). Future clinical trials to evaluate vaccines and other interventions to prevent HIV will need to enroll populations with high HIV incidence. We conducted an observational study of HIV incidence among men and women with multiple sexual partners—including MSM and FSW—in Maputo, Mozambique, in order to prepare the country to conduct future efficacy trials of candidate HIV vaccines and other HIV prevention products.

Methods

We conducted a prospective observational HIV incidence study in Maputo, Mozambique, that enrolled adults aged 18–35 years, without HIV, who had two or more sexual partners in the preceding three months. Recruitment strategies prioritized participation of MSM and FSW. Participants were followed for 24 months with HIV-1 testing every 3 months and staff-administered behavioral questionnaires every 6 months. Cox proportional hazard modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for factors potentially associated with HIV acquisition.

Results

From January 2014 to October 2017, 505 adults without HIV were enrolled with median age of 21 years (interquartile range:19–24); 41% were female and 82% were single. There were 19 HIV seroconversions (10 female and 9 male) during 943 person-years (PY) of observation (overall HIV incidence 2.02/100PY; 95%CI 1.21–3.15). The highest HIV incidence was observed among sex workers (2.08/100PY; 95%CI 0.25–7.52) and MSM (19.18/100PY; 95%CI 3.96–56.06). Increased hazard of incident HIV was observed among participants who were MSM (HR = 27.95, 95%CI 4.39–117.94), p = 0.0004), reported three or more sexual partners at enrollment (HR = 7.39, 95%CI 1.64–33.25, p = 0.009), and indicated ever having a sexual partner living with HIV (HR = 9.64, 95%CI 2.23–41.71, p = 0.002).

Conclusion

Our findings may inform inclusion criteria for upcoming clinical trials of HIV prevention interventions, including vaccine candidates, which may prioritize enrollment of MSM, people with more than three sexual partners, and people with sexual partners who are living with HIV. These same populations are in need of further intervention to reduce HIV incidence.