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Background <p>Fatigue is one of the main symptoms in anxiety or mood disorders (AMDs). Despite this, different qualitative subjective fatigue dimensions (e.g., physical fatigue, mental fatigue, etc.) have not been researched in relation to depression and especially anxiety symptom severity. The current study examined the associations between depression and anxiety symptom severity and fatigue characteristics in individuals with AMDs.</p> Methods <p>A total of 233 individuals with AMDs who were attending a psychiatric daycare unit (78.5% women, mean age 39.0 years) participated in this cross-sectional study. Participants completed the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Multidimensional Fatigue Inventory-20 (MFI-20) self-report questionnaires.</p> Results <p>Multivariable regression analysis found that PHQ-9 depression symptom severity was associated with general fatigue (b = 0.366, <i>p</i> &lt; 0.001), physical fatigue (b = 0.503, <i>p</i> &lt; 0.001), reduced activity (b = 0.603, <i>p</i> &lt; 0.001), reduced motivation (b = 0.511, <i>p</i> &lt; 0.001), and mental fatigue (b = 0.459, <i>p</i> &lt; 0.001), according to the MFI-20. GAD-7 anxiety symptom severity was associated with MFI-20 general fatigue (b = 0.185, <i>p</i> = 0.032). Analyses were controlled for age, sex, education, body mass index, smoking, and current medication use. Analyses in comorbid AMDs showed that fatigue was consistently linked to depression severity but not to anxiety severity.</p> Conclusions <p>In individuals with AMDs, depression symptom severity was linked to all subjective fatigue characteristics and that is particularly prevalent in individuals with comorbid AMDs. Anxiety symptom severity showed weaker, more specific associations with subjective fatigue characteristics. These results show the importance of assessing and addressing specific fatigue characteristics in the clinical management of AMDs.</p>

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Depression and anxiety symptom severity correlates with subjective fatigue characteristics in individuals with anxiety and mood disorders

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月1日

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  • Agne Stanyte,
  • Naomi A. Fineberg,
  • Katharina Domschke,
  • Aurelija Podlipskyte,
  • Julija Gecaite-Stonciene,
  • Jurate Macijauskiene,
  • Vesta Steibliene,
  • Julius Burkauskas

摘要

Background

Fatigue is one of the main symptoms in anxiety or mood disorders (AMDs). Despite this, different qualitative subjective fatigue dimensions (e.g., physical fatigue, mental fatigue, etc.) have not been researched in relation to depression and especially anxiety symptom severity. The current study examined the associations between depression and anxiety symptom severity and fatigue characteristics in individuals with AMDs.

Methods

A total of 233 individuals with AMDs who were attending a psychiatric daycare unit (78.5% women, mean age 39.0 years) participated in this cross-sectional study. Participants completed the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Multidimensional Fatigue Inventory-20 (MFI-20) self-report questionnaires.

Results

Multivariable regression analysis found that PHQ-9 depression symptom severity was associated with general fatigue (b = 0.366, p < 0.001), physical fatigue (b = 0.503, p < 0.001), reduced activity (b = 0.603, p < 0.001), reduced motivation (b = 0.511, p < 0.001), and mental fatigue (b = 0.459, p < 0.001), according to the MFI-20. GAD-7 anxiety symptom severity was associated with MFI-20 general fatigue (b = 0.185, p = 0.032). Analyses were controlled for age, sex, education, body mass index, smoking, and current medication use. Analyses in comorbid AMDs showed that fatigue was consistently linked to depression severity but not to anxiety severity.

Conclusions

In individuals with AMDs, depression symptom severity was linked to all subjective fatigue characteristics and that is particularly prevalent in individuals with comorbid AMDs. Anxiety symptom severity showed weaker, more specific associations with subjective fatigue characteristics. These results show the importance of assessing and addressing specific fatigue characteristics in the clinical management of AMDs.