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Background <p>Mental health disorders cause substantial patient suffering, which could be alleviated through early diagnostic biomarkers. While biomarker discovery is costly, genetic methods utilizing data from large-scale studies, such as Mendelian randomization, may provide a cost-effective approach.</p> Methods <p>A two-sample Mendelian randomization analysis was conducted to identify potential urinary biomarkers of seven psychiatric disorders using summary statistics from GWAS data.</p> Results <p>The analysis revealed 67 analyte-disorder associations, of which 21 were exclusive to a single disorder. Notable associations were observed between tyrosine and schizophrenia (β = -0.041, SE = 0.013, Q = 0.027), creatine and bipolar disorder (β = -0.077, SE = 0.019, Q = 0.002), pyridoxal (β = 0.10, SE = 0.03, Q = 0.042) and ferulic acid 4-sulfate (β =  0.077, SE = 0.025, Q = 0.037) to anorexia nervosa, and N, N-dimethylglycine to ADHD (β = -0.39, SE = 0.11, Q = 0.008).</p> Conclusion <p>The results identify candidate urinary biomarkers and demonstrate the utility of genetic instruments for biomarker discovery, warranting experimental validation in independent cohorts.</p> Clinical trial number <p>Not applicable.</p>

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Discovery of urinary metabolite biomarkers of psychiatric disorders using two-sample Mendelian randomization

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月7日

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  • Jihan K. Zaki,
  • Jakub Tomasik,
  • Jade A. McCune,
  • Oren A. Scherman,
  • Sabine Bahn

摘要

Background

Mental health disorders cause substantial patient suffering, which could be alleviated through early diagnostic biomarkers. While biomarker discovery is costly, genetic methods utilizing data from large-scale studies, such as Mendelian randomization, may provide a cost-effective approach.

Methods

A two-sample Mendelian randomization analysis was conducted to identify potential urinary biomarkers of seven psychiatric disorders using summary statistics from GWAS data.

Results

The analysis revealed 67 analyte-disorder associations, of which 21 were exclusive to a single disorder. Notable associations were observed between tyrosine and schizophrenia (β = -0.041, SE = 0.013, Q = 0.027), creatine and bipolar disorder (β = -0.077, SE = 0.019, Q = 0.002), pyridoxal (β = 0.10, SE = 0.03, Q = 0.042) and ferulic acid 4-sulfate (β =  0.077, SE = 0.025, Q = 0.037) to anorexia nervosa, and N, N-dimethylglycine to ADHD (β = -0.39, SE = 0.11, Q = 0.008).

Conclusion

The results identify candidate urinary biomarkers and demonstrate the utility of genetic instruments for biomarker discovery, warranting experimental validation in independent cohorts.

Clinical trial number

Not applicable.