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Background <p>Appetite loss is frequent in patients with major depressive disorders (MDD). However, research on the association between appetite loss and psychopathology symptoms in adolescents with MDD remains limited, particularly regarding gender differences. Therefore, this study aimed to explore these associations and potential gender differences.</p> Methods <p>A cross-sectional study carried out between January to December 2021 in eight hospitals, recruiting 364 adolescents with MDD. It utilized the Hamilton Depression Scale (HAMD), the Positive and Negative Suicide Ideation Scale for Adolescents (PANSI), the Chinese version of the Epworth Sleepiness Scale (ESS), the Insomnia Severity Index (ISI), and the Chinese version of the Internet Addiction Test (IAT) to assess patients’ depressive severity, suicidal ideation, sleepiness, insomnia, and internet addiction, respectively. Logistic regression was employed to examine the independent factors with an impact on appetite loss.</p> Results <p>The prevalence of appetite loss was 69.2% in adolescents with MDD and 74.7% in female patients. Regression results indicated that appetite loss was independently correlated with Gender (OR = 0.559, 95% CI = 0.331 ~ 0.944, <i>p</i> = 0.029), BMI (OR = 0.925, 95% CI = 0.876 ~ 0.977, <i>p</i> = 0.005), HAMD score (OR = 1.080, 95% CI = 1.041 ~ 1.120, <i>p</i> &lt; 0.001) and ISI score (OR = 1.073, 95% CI = 1.024 ~ 1.124, <i>p</i> = 0.003). When discussing gender differences, it was found that female patients were independently associated with BMI, HAMD score and ISI score, while male patients were only independently associated with HAMD score. Finally, the receiver operating characteristic (ROC) curve results showed that combining Gender, BMI, HAMD score, and ISI score predicted appetite loss well (AUC = 0.746). In female patients, the combined prediction of BMI, HAMD score, ESS score, and ISI score demonstrated predictive value for appetite loss (AUC = 0.732). In male patients, the HAMD score served as an effective predictor (AUC = 0.713).</p> Conclusion <p>Adolescents with MDD, particularly females, faced a heightened risk of appetite loss. Additionally, appetite loss was significantly associated with multiple clinical symptoms, and these associations showed certain gender differences.</p> Clinical trial number <p>Not applicable.</p>

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Associations between appetite loss and psychopathology as well as gender differences in adolescents with major depressive disorders

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月25日

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  • Jinyue Xue,
  • Lewei Liu,
  • Jingwen Shang,
  • Yachen Feng,
  • Xianlin Sun,
  • Jiawei Wang,
  • Changhao Chen,
  • Zhiwei Liu,
  • Feng Geng,
  • Daming Mo,
  • Xiangfen Luo,
  • Xiangwang Wen,
  • Lei Xia,
  • Huanzhong Liu

摘要

Background

Appetite loss is frequent in patients with major depressive disorders (MDD). However, research on the association between appetite loss and psychopathology symptoms in adolescents with MDD remains limited, particularly regarding gender differences. Therefore, this study aimed to explore these associations and potential gender differences.

Methods

A cross-sectional study carried out between January to December 2021 in eight hospitals, recruiting 364 adolescents with MDD. It utilized the Hamilton Depression Scale (HAMD), the Positive and Negative Suicide Ideation Scale for Adolescents (PANSI), the Chinese version of the Epworth Sleepiness Scale (ESS), the Insomnia Severity Index (ISI), and the Chinese version of the Internet Addiction Test (IAT) to assess patients’ depressive severity, suicidal ideation, sleepiness, insomnia, and internet addiction, respectively. Logistic regression was employed to examine the independent factors with an impact on appetite loss.

Results

The prevalence of appetite loss was 69.2% in adolescents with MDD and 74.7% in female patients. Regression results indicated that appetite loss was independently correlated with Gender (OR = 0.559, 95% CI = 0.331 ~ 0.944, p = 0.029), BMI (OR = 0.925, 95% CI = 0.876 ~ 0.977, p = 0.005), HAMD score (OR = 1.080, 95% CI = 1.041 ~ 1.120, p < 0.001) and ISI score (OR = 1.073, 95% CI = 1.024 ~ 1.124, p = 0.003). When discussing gender differences, it was found that female patients were independently associated with BMI, HAMD score and ISI score, while male patients were only independently associated with HAMD score. Finally, the receiver operating characteristic (ROC) curve results showed that combining Gender, BMI, HAMD score, and ISI score predicted appetite loss well (AUC = 0.746). In female patients, the combined prediction of BMI, HAMD score, ESS score, and ISI score demonstrated predictive value for appetite loss (AUC = 0.732). In male patients, the HAMD score served as an effective predictor (AUC = 0.713).

Conclusion

Adolescents with MDD, particularly females, faced a heightened risk of appetite loss. Additionally, appetite loss was significantly associated with multiple clinical symptoms, and these associations showed certain gender differences.

Clinical trial number

Not applicable.