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Background <p>Schizophrenia is a severe chronic mental disorder characterized by hallucinations, delusions, and disorganized speech and behavior. On the other hand, isovaleric acidemia (IVA) is a rare metabolic disorder characterized by the accumulation of isovaleric acid and its metabolic byproducts in the body. To date, there is a notable absence of clinical descriptions concerning the simultaneous occurrence of IVA and schizophrenia in the existing literature.</p> Case presentation <p>This report presents a clinical case involving the coexistence of IVA and Schizophrenia. A 25-year-old male patient diagnosed with comorbid IVA and schizophrenia was admitted to the psychiatric department due to worsening delusions and auditory hallucinations. Treatment with antipsychotics (clozapine 150&#xa0;mg/day and blonanserin 24&#xa0;mg/day) and metabolic agents (L-carnitine 3&#xa0;g/day and reduced glutathione 1.2&#xa0;g/day) reduced delusion severity, though delusions persisted, while auditory hallucinations resolved.</p> Conclusions <p>In this case description, the authors describe a rare clinical case in which the patient presents with IVA and schizophrenia. This case discusses the potential pathways through which IVA may precipitate the onset of schizophrenia.</p>

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A rare case of isovaleric acidemia and schizophrenia: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • Jiawei Zhou,
  • Hui Chen,
  • Xianliang Chen,
  • Huajia Tang,
  • Sihong Li,
  • Jiansong Zhou

摘要

Background

Schizophrenia is a severe chronic mental disorder characterized by hallucinations, delusions, and disorganized speech and behavior. On the other hand, isovaleric acidemia (IVA) is a rare metabolic disorder characterized by the accumulation of isovaleric acid and its metabolic byproducts in the body. To date, there is a notable absence of clinical descriptions concerning the simultaneous occurrence of IVA and schizophrenia in the existing literature.

Case presentation

This report presents a clinical case involving the coexistence of IVA and Schizophrenia. A 25-year-old male patient diagnosed with comorbid IVA and schizophrenia was admitted to the psychiatric department due to worsening delusions and auditory hallucinations. Treatment with antipsychotics (clozapine 150 mg/day and blonanserin 24 mg/day) and metabolic agents (L-carnitine 3 g/day and reduced glutathione 1.2 g/day) reduced delusion severity, though delusions persisted, while auditory hallucinations resolved.

Conclusions

In this case description, the authors describe a rare clinical case in which the patient presents with IVA and schizophrenia. This case discusses the potential pathways through which IVA may precipitate the onset of schizophrenia.