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Background <p>Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.</p> Methods <p>This cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.</p> Results <p>A total of 14,557 subjects were included in this study, of whom, 1231 (8.5%) had depression. According to multivariate logistic regression and RCS analyses, a significantly linearly positive correlation was observed between IBI and depression [odds ratio (OR) = 1.03, 95% confidence intervals (CI): 1.01, 1.05, <i>P</i> = 0.007]. Subjects in the third tertile of IBI exhibited a significantly higher prevalence of depression, with 40.0% affected, compared to those in the first tertile (<i>P</i> &lt; 0.001). This correlation was consistently observed across all subgroups through stratified analysis (all interaction <i>P</i> &gt; 0.05). After sensitivity analyses excluding participants with upper and lower 2.5% of IBI, the correlation between IBI and depression remained stable (OR = 1.08; 95%CI, 1.01, 1.15, <i>P</i> &lt; 0.001).</p> Conclusion <p>These findings in this study indicate a positive correlation between IBI and depression in American adults. Further large-scale prospective studies are still needed to analyze the role of IBI in depression.</p>

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Inflammatory burden index is correlated with increased depression: a population-based study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月31日

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  • Xiangzhi Shao,
  • Zuopu Xie,
  • Lielie Zhu

摘要

Background

Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.

Methods

This cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.

Results

A total of 14,557 subjects were included in this study, of whom, 1231 (8.5%) had depression. According to multivariate logistic regression and RCS analyses, a significantly linearly positive correlation was observed between IBI and depression [odds ratio (OR) = 1.03, 95% confidence intervals (CI): 1.01, 1.05, P = 0.007]. Subjects in the third tertile of IBI exhibited a significantly higher prevalence of depression, with 40.0% affected, compared to those in the first tertile (P < 0.001). This correlation was consistently observed across all subgroups through stratified analysis (all interaction P > 0.05). After sensitivity analyses excluding participants with upper and lower 2.5% of IBI, the correlation between IBI and depression remained stable (OR = 1.08; 95%CI, 1.01, 1.15, P < 0.001).

Conclusion

These findings in this study indicate a positive correlation between IBI and depression in American adults. Further large-scale prospective studies are still needed to analyze the role of IBI in depression.