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<p>Anti-IL-23 autoantibodies are associated with severe, persistent opportunistic infections. We described the first pediatric case of <i>Saccharomyces cerevisiae</i> fungemia with high anti-IL-23 autoantibodies, which was successfully treated using the novel application of daratumumab, resulting in significant clinical and laboratory improvements.</p>

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Rare pediatric Saccharomyces cerevisiae fungemia with neutralizing anti-IL-23 autoantibodies: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月24日

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  • Yajuan Zhou,
  • Rui Song,
  • Xiaoxiang Chen,
  • Qing Cao

摘要

Anti-IL-23 autoantibodies are associated with severe, persistent opportunistic infections. We described the first pediatric case of Saccharomyces cerevisiae fungemia with high anti-IL-23 autoantibodies, which was successfully treated using the novel application of daratumumab, resulting in significant clinical and laboratory improvements.