Scholarlink

Background <p>Clear cell hidradenoma (CCH) of the breast is an exceedingly rare benign adnexal tumor. Its clinical and radiological presentation can closely mimic malignancy, posing a significant diagnostic challenge.</p> Case presentation <p>We report a case of a 6-year-old boy presenting with a non-healing, ulcerated nodule on the left nipple-areolar complex. Ultrasonography revealed a lobulated, cystic nodule. An ultrasound-guided core needle biopsy was performed, revealing epithelial cells with clear cytoplasm, warranting excision. The lesion was completely excised. Histopathology confirmed CCH, but an involved lateral margin necessitated a successful re-excision. Immunohistochemistry (IHC) on the excised specimen showed tumor cells positive for p63, Cytokeratin, and EMA, and negative for SMA, CD10, ER, and PR. The patient remains disease-free at 12 months.</p> Conclusion <p>To our knowledge, this is the youngest male reported with breast CCH. This case highlights the diagnostic pitfall where CCH mimics malignancy and underscores the critical role of histopathology and IHC, particularly p63 positivity and myoepithelial marker negativity, in reaching an accurate diagnosis. Complete surgical excision with clear margins is the definitive treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The youngest male breast clear cell hidradenoma case: a literature review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月13日

查看全文
  • Yavuz Yilmaz,
  • Sukruye Demirkaya,
  • Esra Karakus,
  • Seda Sahin

摘要

Background

Clear cell hidradenoma (CCH) of the breast is an exceedingly rare benign adnexal tumor. Its clinical and radiological presentation can closely mimic malignancy, posing a significant diagnostic challenge.

Case presentation

We report a case of a 6-year-old boy presenting with a non-healing, ulcerated nodule on the left nipple-areolar complex. Ultrasonography revealed a lobulated, cystic nodule. An ultrasound-guided core needle biopsy was performed, revealing epithelial cells with clear cytoplasm, warranting excision. The lesion was completely excised. Histopathology confirmed CCH, but an involved lateral margin necessitated a successful re-excision. Immunohistochemistry (IHC) on the excised specimen showed tumor cells positive for p63, Cytokeratin, and EMA, and negative for SMA, CD10, ER, and PR. The patient remains disease-free at 12 months.

Conclusion

To our knowledge, this is the youngest male reported with breast CCH. This case highlights the diagnostic pitfall where CCH mimics malignancy and underscores the critical role of histopathology and IHC, particularly p63 positivity and myoepithelial marker negativity, in reaching an accurate diagnosis. Complete surgical excision with clear margins is the definitive treatment.