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Objective <p>To investigate the physical growth and neurodevelopmental indicators of Gestational age(GA)&lt; 32 weeks infants at 6 months corrected age.</p> Methods <p>This study included 116 infants, retrospectively analyzing GA&lt;32 weeks infants who discharged from Tianjin Central Hospital of Gynecology and Obstetrics between April 2023 and August 2024. General movements (GMs) assessment was performed at 1 month corrected age. Physical Growth Indicators, GMs and Gesell Developmental Diagnosis Scale (GDDS) assessments were conducted at 3 and 6 months corrected age.</p> Results <p>The proportion of abnormal GMs at 3 months corrected age (3.44%) was lower than that at 1 month corrected age (86.21%).At 6 months corrected age, the proportion of infants with a developmental quotient (DQ) ≤ 75 was 43.10%, lower than 69.82% at 3 months corrected age. GA and multiple births were independent risk factors for DQ ≤ 75 at 3 months corrected age. GA, early intervention, and intracranial hemorrhage were independent risk factors for DQ ≤ 75 at 6 months corrected age.</p> Conclusion <p>At 6 months corrected age, GA&lt;32 weeks infants exhibited greater neurodevelopmental outcome. Standardized follow-up and early neurodevelopmental interventions should be further strengthened for preterm infants to reduce the occurrence of adverse outcomes.</p>

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Physical growth and neurodevelopmental indicators at corrected 6 months of age in preterm infants born at 22–32 weeks gestation: a single-center study

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  • 发表日期：

    2025年12月15日

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  • Zhongfu Guo,
  • Chao Ning,
  • Wanxian Zhang,
  • Dingning Zhang,
  • Fangrui Ding

摘要

Objective

To investigate the physical growth and neurodevelopmental indicators of Gestational age(GA)< 32 weeks infants at 6 months corrected age.

Methods

This study included 116 infants, retrospectively analyzing GA<32 weeks infants who discharged from Tianjin Central Hospital of Gynecology and Obstetrics between April 2023 and August 2024. General movements (GMs) assessment was performed at 1 month corrected age. Physical Growth Indicators, GMs and Gesell Developmental Diagnosis Scale (GDDS) assessments were conducted at 3 and 6 months corrected age.

Results

The proportion of abnormal GMs at 3 months corrected age (3.44%) was lower than that at 1 month corrected age (86.21%).At 6 months corrected age, the proportion of infants with a developmental quotient (DQ) ≤ 75 was 43.10%, lower than 69.82% at 3 months corrected age. GA and multiple births were independent risk factors for DQ ≤ 75 at 3 months corrected age. GA, early intervention, and intracranial hemorrhage were independent risk factors for DQ ≤ 75 at 6 months corrected age.

Conclusion

At 6 months corrected age, GA<32 weeks infants exhibited greater neurodevelopmental outcome. Standardized follow-up and early neurodevelopmental interventions should be further strengthened for preterm infants to reduce the occurrence of adverse outcomes.