Scholarlink

Introduction <p>Neonatal Hyperbilirubinemia (NH) is one of the most common clinical presentations in the first week of life.</p> Aims <p>This study sought to determine the incidence, clinical presentation and risk factors associated with mortality, among neonates presenting with unconjugated NH at the Komfo Anokye Teaching Hospital in Ghana.</p> Methodology <p>This was a hospital-based prospective analytical cohort study conducted from October to December 2020. A total of 223 newborns admitted to the nursery with NH were recruited, mothers were interviewed, and patients were followed-up until discharge. Data was collected and analyzed with R statistical software. Associations were determined as crude and adjusted odds ratios using univariate and multivariate binomial logistic regression.</p> Results <p>The incidence of NH was 244 per 1000 admissions (95% CI: 21.7–27.3) with a case fatality rate of 8.1% (95% CI: 4.8–12.4). Independent predictors of increased mortality were older age at admission [AOR = 1.28(1.05–1.57), <i>p</i> = 0.015], gestational age between 35 and 37 weeks [AOR = 4.89(1.04–25.8), <i>p</i> = 0.047], and the presence of abnormal posture at admission [AOR = 6.40(1.37–35.9), <i>p</i> = 0.023]. The presentations associated with survival till discharge were primiparity in the mother [AOR = 0.06(0.01, 0.32), <i>p</i> = 0.003], and exclusive breastfeeding at the time of admission [AOR = 0.09 (0.02–0.46), <i>p</i> = 0.004].</p> Conclusion <p>The incidence of hyperbilirubinemia among neonates admitted to the Mother Baby Unit at KATH is high and gestational ages between 35 and 37 weeks, abnormal posture and older age at presentation were identified to be significantly associated with mortality.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Outcomes of neonatal hyperbilirubinemia and associated factors at a tertiary hospital in Ghana

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月2日

查看全文
  • Naana Ayiwa Wireko Brobby,
  • Samuel Blay Nguah,
  • Rafiuk Cosmos Yakubu,
  • Gyikua Plange-Rhule,
  • Adwoa P. Boakye Yiadom,
  • Akua Afriyie Ocran,
  • Joyce Ashong

摘要

Introduction

Neonatal Hyperbilirubinemia (NH) is one of the most common clinical presentations in the first week of life.

Aims

This study sought to determine the incidence, clinical presentation and risk factors associated with mortality, among neonates presenting with unconjugated NH at the Komfo Anokye Teaching Hospital in Ghana.

Methodology

This was a hospital-based prospective analytical cohort study conducted from October to December 2020. A total of 223 newborns admitted to the nursery with NH were recruited, mothers were interviewed, and patients were followed-up until discharge. Data was collected and analyzed with R statistical software. Associations were determined as crude and adjusted odds ratios using univariate and multivariate binomial logistic regression.

Results

The incidence of NH was 244 per 1000 admissions (95% CI: 21.7–27.3) with a case fatality rate of 8.1% (95% CI: 4.8–12.4). Independent predictors of increased mortality were older age at admission [AOR = 1.28(1.05–1.57), p = 0.015], gestational age between 35 and 37 weeks [AOR = 4.89(1.04–25.8), p = 0.047], and the presence of abnormal posture at admission [AOR = 6.40(1.37–35.9), p = 0.023]. The presentations associated with survival till discharge were primiparity in the mother [AOR = 0.06(0.01, 0.32), p = 0.003], and exclusive breastfeeding at the time of admission [AOR = 0.09 (0.02–0.46), p = 0.004].

Conclusion

The incidence of hyperbilirubinemia among neonates admitted to the Mother Baby Unit at KATH is high and gestational ages between 35 and 37 weeks, abnormal posture and older age at presentation were identified to be significantly associated with mortality.