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Background <p>Gastrointestinal (GI) manifestations have been reported as the most extra-pulmonary manifestations of coronavirus disease 2019 (COVID-19). Recognizing the various manifestations, especially as presenting symptoms of COVID-19 is of great importance. We aimed to investigate the GI and hepatic manifestations of COVID − 19 in children, determining the factors associated with the disease severity and prognosis related to GI symptoms.</p> Methods <p>In this retrospective study, children aged 1-month to 16-years who were admitted to Afzalipour Hospital in Kerman, Iran. for a period of one year (from October 2020 to October 2021) with the diagnosis of COVID-19 were included. The comparison of clinical symptoms and laboratory variables in the appendectomy and non-appendectomy groups were evaluated. Patients’ information was extracted from the patient’s medical record and analyzed in SPSS statistical. software.</p> Results <p>A total of 163 patients (107 boy and 56 girls) with mean age of 4.35 ± 3.86 (range 0.08 to 16) years were included. The most frequent GI symptoms at the time of admission were watery diarrhea (46.6%), vomiting (45.4%), and abdominal pain (32.5%). There was no significant relationship between clinical symptoms and laboratory variables in the appendectomy and non-appendectomy groups, but the severity of COVID-19 was significantly associated with appendicitis (<i>P</i> = 0.03). There was no statistically significant relationship between liver enzyme levels and disease severity and pediatric intensive care unit admission.</p> Conclusions <p>Although most COVID-19 patients present with GI manifestations, we could not determine the relationship between GI and hepatic manifestations and disease severity in this study.</p> Clinical trial number <p>Not applicable.</p>

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Gastrointestinal and hepatic manifestations among hospitalized COVID-19 children

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月17日

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  • Reza Sinaei,
  • Ali Hosseininasab,
  • Parvin Abbaslou,
  • Mazyar Zeinali,
  • Elham Iranmanesh,
  • Roya Sinaei,
  • Keramat Rahmanian

摘要

Background

Gastrointestinal (GI) manifestations have been reported as the most extra-pulmonary manifestations of coronavirus disease 2019 (COVID-19). Recognizing the various manifestations, especially as presenting symptoms of COVID-19 is of great importance. We aimed to investigate the GI and hepatic manifestations of COVID − 19 in children, determining the factors associated with the disease severity and prognosis related to GI symptoms.

Methods

In this retrospective study, children aged 1-month to 16-years who were admitted to Afzalipour Hospital in Kerman, Iran. for a period of one year (from October 2020 to October 2021) with the diagnosis of COVID-19 were included. The comparison of clinical symptoms and laboratory variables in the appendectomy and non-appendectomy groups were evaluated. Patients’ information was extracted from the patient’s medical record and analyzed in SPSS statistical. software.

Results

A total of 163 patients (107 boy and 56 girls) with mean age of 4.35 ± 3.86 (range 0.08 to 16) years were included. The most frequent GI symptoms at the time of admission were watery diarrhea (46.6%), vomiting (45.4%), and abdominal pain (32.5%). There was no significant relationship between clinical symptoms and laboratory variables in the appendectomy and non-appendectomy groups, but the severity of COVID-19 was significantly associated with appendicitis (P = 0.03). There was no statistically significant relationship between liver enzyme levels and disease severity and pediatric intensive care unit admission.

Conclusions

Although most COVID-19 patients present with GI manifestations, we could not determine the relationship between GI and hepatic manifestations and disease severity in this study.

Clinical trial number

Not applicable.