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Background <p>Toxoplasma retinochoroiditis is challenging to diagnose and treat, especially in immunocompromised or co-infected individuals. This report describes a complex vision loss case in a syphilis and tuberculosis-history patient, demonstrating the utility of multi-omics in guiding diagnosis and treatment.</p> Case Summary <p>A 50-year-old female with treated syphilis and tuberculosis had right eye floaters and visual disturbances, with panuveitis and retinal lesions on exam. Aqueous humor multi-omics confirmed Toxoplasma gondii (no syphilis or tuberculosis DNA), and she recovered with 8-week trimethoprim-sulfamethoxazole plus tapered prednisone (initiated 72h post-antimicrobial therapy).</p> Conclusion <p>This case highlights the diagnostic challenges of ocular inflammation in patients with co-infections and demonstrates the value of multi-omics-guided intraocular fluid analysis for precise pathogen identification. This case supports a combined treatment strategy of anti-toxoplasmosis medication and cautious corticosteroid use, which—despite the risk of reactivating latent infections—can achieve excellent anatomical and visual outcomes.</p>

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Multi-omics-guided diagnosis and treatment of toxoplasma retinochoroiditis with co-infection: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月11日

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  • Qiongjun Xie,
  • Jingyue Deng,
  • Caiyin Mo,
  • Xiaoshan Lin,
  • Qian Shi,
  • Anyi Liang,
  • Guanghua Zhou

摘要

Background

Toxoplasma retinochoroiditis is challenging to diagnose and treat, especially in immunocompromised or co-infected individuals. This report describes a complex vision loss case in a syphilis and tuberculosis-history patient, demonstrating the utility of multi-omics in guiding diagnosis and treatment.

Case Summary

A 50-year-old female with treated syphilis and tuberculosis had right eye floaters and visual disturbances, with panuveitis and retinal lesions on exam. Aqueous humor multi-omics confirmed Toxoplasma gondii (no syphilis or tuberculosis DNA), and she recovered with 8-week trimethoprim-sulfamethoxazole plus tapered prednisone (initiated 72h post-antimicrobial therapy).

Conclusion

This case highlights the diagnostic challenges of ocular inflammation in patients with co-infections and demonstrates the value of multi-omics-guided intraocular fluid analysis for precise pathogen identification. This case supports a combined treatment strategy of anti-toxoplasmosis medication and cautious corticosteroid use, which—despite the risk of reactivating latent infections—can achieve excellent anatomical and visual outcomes.