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Background <p>To investigate the relationship between ocular and hand dominance patterns in healthy volunteers and to evaluate structural differences between dominant and non-dominant eyes using anterior and posterior segment measurements.</p> Methods <p>This cross-sectional study included 524 healthy volunteers (50% female, age 20–60). Ocular dominance was determined using the hole-in-card test and hand dominance with the Edinburgh Handedness Inventory. Participants underwent Swept-Source Optical Coherence Tomography for retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), subfoveal choroidal thickness (SFCT), and choroidal vascularity index (CVI) measurements; Scheimpflug imaging for anterior segment parameters; and partial coherence interferometry for axial length determination.</p> Results <p>Right eye dominance was observed in 60.9% and left eye dominance in 39.1% of participants. A pronounced cross-lateralization pattern emerged: 93.6% of left eye dominant individuals exhibited right hand dominance, significantly higher than in right eye dominant participants (57.1% right-handed, <i>p</i> = 0.024; 42.9% left-handed, <i>p</i> = 0.016). After correction for multiple comparisons, dominant eyes demonstrated significantly greater central corneal thickness (<i>p</i> = 0.002). RNFL nasal quadrant thickness showed the strongest trend toward significance (<i>p</i> = 0.014). Axial length, additional RNFL quadrants, and GCC sectors demonstrated consistent trends toward significance. No differences were found in SFCT or CVI.</p> Conclusions <p>Dominant eyes demonstrated significantly greater central corneal thickness after correction for multiple comparisons, with nasal RNFL thickness showing the strongest trend toward significance. A differential lateralization pattern was observed between ocular dominance groups, suggesting a potential association between ocular and manual preferences; however, this finding warrants cautious interpretation given the population-level prevalence of right-handedness.</p> Trial registration <p>This cross-sectional study was approved by the Institutional Ethics Committee of İzmir Democracy University, Buca Seyfi Demirsoy Training and Research Hospital (date: 26.03.2025; number: 2025/427) and adhered to the principles of the Declaration of Helsinki.</p>

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Hand-eye laterality and structural asymmetry between dominant and non-dominant eyes: a multi-modal study in 524 healthy volunteers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月24日

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  • Pelin Kiyat,
  • Melis Palamar

摘要

Background

To investigate the relationship between ocular and hand dominance patterns in healthy volunteers and to evaluate structural differences between dominant and non-dominant eyes using anterior and posterior segment measurements.

Methods

This cross-sectional study included 524 healthy volunteers (50% female, age 20–60). Ocular dominance was determined using the hole-in-card test and hand dominance with the Edinburgh Handedness Inventory. Participants underwent Swept-Source Optical Coherence Tomography for retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), subfoveal choroidal thickness (SFCT), and choroidal vascularity index (CVI) measurements; Scheimpflug imaging for anterior segment parameters; and partial coherence interferometry for axial length determination.

Results

Right eye dominance was observed in 60.9% and left eye dominance in 39.1% of participants. A pronounced cross-lateralization pattern emerged: 93.6% of left eye dominant individuals exhibited right hand dominance, significantly higher than in right eye dominant participants (57.1% right-handed, p = 0.024; 42.9% left-handed, p = 0.016). After correction for multiple comparisons, dominant eyes demonstrated significantly greater central corneal thickness (p = 0.002). RNFL nasal quadrant thickness showed the strongest trend toward significance (p = 0.014). Axial length, additional RNFL quadrants, and GCC sectors demonstrated consistent trends toward significance. No differences were found in SFCT or CVI.

Conclusions

Dominant eyes demonstrated significantly greater central corneal thickness after correction for multiple comparisons, with nasal RNFL thickness showing the strongest trend toward significance. A differential lateralization pattern was observed between ocular dominance groups, suggesting a potential association between ocular and manual preferences; however, this finding warrants cautious interpretation given the population-level prevalence of right-handedness.

Trial registration

This cross-sectional study was approved by the Institutional Ethics Committee of İzmir Democracy University, Buca Seyfi Demirsoy Training and Research Hospital (date: 26.03.2025; number: 2025/427) and adhered to the principles of the Declaration of Helsinki.