Background <p>The objective of this study was to evaluate the anatomical and functional outcomes of patients who underwent relaxing retinotomy or retinectomy for retinal detachment complicated by proliferative vitreoretinopathy.</p> Methods <p>The medical records of all patients who underwent retinectomy for retinal detachment complicated with proliferative vitreoretinopathy between 2015 and 2023 were reviewed retrospectively.</p> Results <p>The patients’ mean age was 60.83 ± 16.4 (21–90) years. The study population consisted of 28 male (42.4%) and 38 female (57.6%). The mean follow-up period was 21.72 ± 13.44 (12–65) months. The mean initial visual acuity was 2.1 ± 0.63 logMAR, while the mean final visual acuity was 1.94 ± 0.69 logMAR (<i>p</i> = 0.094). Twenty-one patients presented with rhegmatogenous retinal detachment (31.8%), 36 with tractional retinal detachment due to diabetes (54.5%), and nine with retinal detachment secondary to trauma (13.6%). Visual acuity increased in 30 patients (45.45%), decreased in 10 patients (15.15%), and did not change in 26 patients (39.39%). Mean intraocular pressure (IOP) values were 13.25 ± 4.67 mmHg (range 5–28) at baseline and 12.98 ± 4.75 mmHg (range 4–25) at the final examination. Twenty-seven patients underwent 90-degree retinectomy (40.9%), 18 underwent 180-degree retinectomy (27.3%), 6 underwent 270-degree retinectomy (9.1%), and 15 underwent 360-degree retinectomy (22.7%). When evaluating proliferative retinal detachment by etiology (rhegmatogenous, traumatic, diabetic), no statistically significant differences were observed in baseline and final visual acuity or intraocular pressure (<i>p</i> &gt; 0.05), nor in recurrence rates (<i>p</i> = 0.42).</p> Conclusion <p>The findings of this study indicate that retinectomy is a beneficial treatment for cases of difficult retinal detachment, particularly when there is a need for both functional vision and retinal stabilization.</p>