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Purpose <p>This study aims to quantitatively assess morphological alterations in cone cells following idiopathic epiretinal membrane (IERM) surgery using adaptive optics scanning light ophthalmoscopy (AO-SLO) and to correlate these findings with retinal structure, retina vascular characteristic and visual function.</p> Method <p>This cross-sectional analysis involved seventeen eyes from 17 patients who underwent IERM surgery, compared to a control group of 35 demographically matched subjects. Comprehensive ophthalmologic evaluations were performed, including AO-SLO, Optical coherence tomography (OCT), and Optical coherence tomography angiography (OCTA). The study focused on assessing post-surgery cone density, dispersion, and regularity, as well as their relationship with visual function, macular structure, and macular vessel characteristics.</p> Result <p>A significant reduction in cone densities and regularity, along with a substantial increase in cone dispersion, were observed in all quadrants of eyes after IERM surgery compared to healthy eyes (mean cone densities: t=-4.76; <i>P</i> &lt; 0.001; mean cone regularity: t=-5.11, <i>P</i> &lt; 0.001; mean cone dispersion: t = 5.56, <i>P</i> &lt; 0.001). Negative correlations were found between cone densities and best-corrected visual acuity (BCVA) (ρ=-0.62, <i>P</i> &lt; 0.001). Additionally, average cone density correlated negatively with inner retinal thickness, particularly in the inferior quadrants (ρ = -0.42, <i>P</i> = 0.03), and with vascular density of the superficial capillary plexus (SCP) in the fovea (ρ = -0.39, <i>P</i> = 0.04), as indicated by OCTA.</p> Conclusion <p>The assessments of cone morphology using AO-SLO demonstrated persistent deviations from typical photoreceptor arrangements after IERM surgery, which are significantly associated with incomplete recovery of visual function. AO-SLO serves as an effective quantitative tool for identifying photoreceptor abnormalities in eyes after IERM surgery.</p>

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Morphologic assessment of photoreceptors after idiopathic epiretinal membrane surgery with adaptive-optics SLO

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月21日

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  • Pengfeng Li,
  • Yijing Zhuang,
  • Dong Fang,
  • Jia Liang,
  • Yingying Diao,
  • Huiyan Zheng,
  • Lu Chen,
  • Shaochong Zhang

摘要

Purpose

This study aims to quantitatively assess morphological alterations in cone cells following idiopathic epiretinal membrane (IERM) surgery using adaptive optics scanning light ophthalmoscopy (AO-SLO) and to correlate these findings with retinal structure, retina vascular characteristic and visual function.

Method

This cross-sectional analysis involved seventeen eyes from 17 patients who underwent IERM surgery, compared to a control group of 35 demographically matched subjects. Comprehensive ophthalmologic evaluations were performed, including AO-SLO, Optical coherence tomography (OCT), and Optical coherence tomography angiography (OCTA). The study focused on assessing post-surgery cone density, dispersion, and regularity, as well as their relationship with visual function, macular structure, and macular vessel characteristics.

Result

A significant reduction in cone densities and regularity, along with a substantial increase in cone dispersion, were observed in all quadrants of eyes after IERM surgery compared to healthy eyes (mean cone densities: t=-4.76; P < 0.001; mean cone regularity: t=-5.11, P < 0.001; mean cone dispersion: t = 5.56, P < 0.001). Negative correlations were found between cone densities and best-corrected visual acuity (BCVA) (ρ=-0.62, P < 0.001). Additionally, average cone density correlated negatively with inner retinal thickness, particularly in the inferior quadrants (ρ = -0.42, P = 0.03), and with vascular density of the superficial capillary plexus (SCP) in the fovea (ρ = -0.39, P = 0.04), as indicated by OCTA.

Conclusion

The assessments of cone morphology using AO-SLO demonstrated persistent deviations from typical photoreceptor arrangements after IERM surgery, which are significantly associated with incomplete recovery of visual function. AO-SLO serves as an effective quantitative tool for identifying photoreceptor abnormalities in eyes after IERM surgery.