Purpose <p>The purpose of this study was to evaluate the systemic pan-immune inflammatory value (PIV) in wet and dry cases of age-related macular degeneration.</p> Methods <p>Patients diagnosed with AMD between 2020 and 2025 were retrospectively identified. The participants were divided into the wet AMD, dry AMD, and control groups. Their complete blood count (CBC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, and C-reactive protein data were obtained. Neutrophil-to-lymphocyte, monocyte-to-lymphocyte, platelet-to-lymphocyte, and neutrophil-to-HDL ratios were calculated. The PIV was calculated as follows: (neutrophil × platelet × monocyte/lymphocyte count). The central macular and subfoveal choroidal thicknesses were measured manually from the spectral domain optical coherence tomography (OCT) images.</p> Results <p>Of the 72 cases included in the study, 25 were wet AMD, 26 were dry AMD, and 21 were controls. According to the statistical analysis, the white blood cell count (7.89 ± 1.82 vs. 6.66 ± 1.75), neutrophil count (5.02 ± 1.42 10⁹/L vs. 4.11 ± 1.35 10⁹/L), monocyte count (0.64 ± 0.16 10⁹/L vs. 0.49 ± 0.18 10⁹/L), and PIV (414.31 ± 268.02 vs. 270.33 ± 161.84) were higher in the wet AMD group than in the dry AMD group. The monocyte count (0.64 ± 0.16 10⁹/L vs. 0.49 ± 0.17 10⁹/L) and PIV (414.31 ± 268.02 vs. 270.13 ± 127.84) were higher in the wet AMD cases than in the control group. No statistically significant difference was found between the dry AMD and control groups.</p> Conclusion <p>In our study, the PIV was statistically significantly higher in the wet AMD group than in the dry AMD and control groups. Obtaining CBC data is a highly cost-effective and practical method for calculating PIV. PIV calculation can be helpful in the follow-up of patients with AMD, especially those at high risk of converting from dry AMD to wet AMD.</p>