Scholarlink

Background <p>To quantitatively evaluate the retinal foveal avascular zone (FAZ) and choroidal vascular and stromal components in children with anisometropic amblyopia using swept-source optical coherence tomography angiography (SS-OCTA), and to investigate the relationship of these measurements with axial length (AL), best-corrected visual acuity (BCVA), and spherical equivalent (SE).</p> Methods <p>This cross-sectional comparative study included 131 eyes of 89 children: amblyopic (<i>n</i> = 42), fellow (<i>n</i> = 42), and control eyes (<i>n</i> = 47). Retinal parameters, including the FAZ and central macular thickness (CMT), as well as choroidal parameters—subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), choroidal vascular volume (CVV), choroidal stromal index (CSI), and choroidal stromal volume (CSV)—were quantitatively evaluated using SS-OCTA.</p> Results <p>Amblyopic eyes had lower BCVA, shorter AL, and higher hypermetropic refractive error. While no difference was detected in FAZ area, the FD-300 value (vascular density in the 300&#xa0;μm ring around the FAZ) was significantly higher in amblyopic eyes compared to the fellow eye. Choroidal analysis: CVI values decreased at 1&#xa0;mm, 3&#xa0;mm nasal, and 6&#xa0;mm nasal; CSI increased at 1&#xa0;mm, 3&#xa0;mm nasal, and 6&#xa0;mm nasal; CSV increased at 3&#xa0;mm nasal and 6&#xa0;mm nasal, suggesting relative differences in choroidal stromal and vascular components. No differences were observed among CVV parameters. SE was positively correlated with BCVA.</p> Conclusion <p>Our study detected microvascular changes in the retina and choroid in children with anisometropic amblyopia. Quantitative parameters obtained with SS-OCTA demonstrated modest effect sizes and limited discriminatory performance; long-term studies are required to clarify their clinical significance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Structural and microvascular changes in anisometropic amblyopia: a comparative analysis of swept-source OCTA

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月17日

查看全文
  • Serap Karaca,
  • Ahmad Kunbaz,
  • Osman Kizilay,
  • Bilge Batu Oto,
  • Gokhan Celik

摘要

Background

To quantitatively evaluate the retinal foveal avascular zone (FAZ) and choroidal vascular and stromal components in children with anisometropic amblyopia using swept-source optical coherence tomography angiography (SS-OCTA), and to investigate the relationship of these measurements with axial length (AL), best-corrected visual acuity (BCVA), and spherical equivalent (SE).

Methods

This cross-sectional comparative study included 131 eyes of 89 children: amblyopic (n = 42), fellow (n = 42), and control eyes (n = 47). Retinal parameters, including the FAZ and central macular thickness (CMT), as well as choroidal parameters—subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), choroidal vascular volume (CVV), choroidal stromal index (CSI), and choroidal stromal volume (CSV)—were quantitatively evaluated using SS-OCTA.

Results

Amblyopic eyes had lower BCVA, shorter AL, and higher hypermetropic refractive error. While no difference was detected in FAZ area, the FD-300 value (vascular density in the 300 μm ring around the FAZ) was significantly higher in amblyopic eyes compared to the fellow eye. Choroidal analysis: CVI values decreased at 1 mm, 3 mm nasal, and 6 mm nasal; CSI increased at 1 mm, 3 mm nasal, and 6 mm nasal; CSV increased at 3 mm nasal and 6 mm nasal, suggesting relative differences in choroidal stromal and vascular components. No differences were observed among CVV parameters. SE was positively correlated with BCVA.

Conclusion

Our study detected microvascular changes in the retina and choroid in children with anisometropic amblyopia. Quantitative parameters obtained with SS-OCTA demonstrated modest effect sizes and limited discriminatory performance; long-term studies are required to clarify their clinical significance.