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Purpose <p>To evaluate axial length changes in myopic children treated with different optical correction methods combined with 0.01% atropine eye drops.</p> Methods <p>This retrospective study included 366 myopic children (366 eyes) from the Eye Hospital of Wenzhou Medical University (January 2021-December 2024). Participants were stratified into six groups: orthokeratology (OK, <i>n</i> = 52), OK + atropine (OKA, <i>n</i> = 50), highly aspherical lenslets (HAL, <i>n</i> = 83), HAL + atropine (HALA, <i>n</i> = 69), single-vision spectacles (SP, <i>n</i> = 65), and SP + atropine (SPA, <i>n</i> = 47). Axial length (AL) elongation after one year was compared using one-way analysis of variance.</p> Results <p>After one year, AL elongation differed significantly across groups (F = 25.345, <i>P</i> &lt; 0.001). The OK (0.25 ± 0.13&#xa0;mm), OKA (0.18 ± 0.14&#xa0;mm), HAL (0.16 ± 0.16&#xa0;mm), HALA (0.08 ± 0.19&#xa0;mm), and SPA (0.23 ± 0.18&#xa0;mm) groups all showed significantly less AL elongation than the SP group (0.39 ± 0.20&#xa0;mm; all <i>P</i> &lt; 0.001). The HALA group demonstrated the strongest effect (<i>P</i> &lt; 0.01 vs. others), and both OKA and HALA outperformed OK (<i>P</i> = 0.036) and HAL (<i>P</i> = 0.004). Adjunctive 0.01% atropine therapy significantly attenuated AL elongation in older children with myopia, with the most pronounced reduction observed in the OKA group (0.03 ± 0.14&#xa0;mm). Among subjects with higher baseline refractive error, both OKA (0.12 ± 0.13&#xa0;mm) and SPA (0.16 ± 0.19&#xa0;mm) groups demonstrated significantly slower AL progression, whereas the HALA (0.12 ± 0.21&#xa0;mm) cohort exhibited comparatively less effective control of AL growth.</p> Conclusion <p>The combination therapy of OK, HAL, or SP with 0.01% atropine significantly slowed myopia progression. Subgroup analysis revealed a differential efficacy: OKA and SPA demonstrated superior control in older children with higher myopia, whereas HALA was more effective in older children with low myopia.</p>

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Comparative efficacy of optical correction methods combined with 0.01% atropine in myopia control

  • 期刊论文

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  • 发表日期：

    2025年11月26日

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  • Minfeng Chen,
  • Huihui Lei,
  • Xianling Yang,
  • Zihan Deng,
  • Jia Qu,
  • Xinjie Mao

摘要

Purpose

To evaluate axial length changes in myopic children treated with different optical correction methods combined with 0.01% atropine eye drops.

Methods

This retrospective study included 366 myopic children (366 eyes) from the Eye Hospital of Wenzhou Medical University (January 2021-December 2024). Participants were stratified into six groups: orthokeratology (OK, n = 52), OK + atropine (OKA, n = 50), highly aspherical lenslets (HAL, n = 83), HAL + atropine (HALA, n = 69), single-vision spectacles (SP, n = 65), and SP + atropine (SPA, n = 47). Axial length (AL) elongation after one year was compared using one-way analysis of variance.

Results

After one year, AL elongation differed significantly across groups (F = 25.345, P < 0.001). The OK (0.25 ± 0.13 mm), OKA (0.18 ± 0.14 mm), HAL (0.16 ± 0.16 mm), HALA (0.08 ± 0.19 mm), and SPA (0.23 ± 0.18 mm) groups all showed significantly less AL elongation than the SP group (0.39 ± 0.20 mm; all P < 0.001). The HALA group demonstrated the strongest effect (P < 0.01 vs. others), and both OKA and HALA outperformed OK (P = 0.036) and HAL (P = 0.004). Adjunctive 0.01% atropine therapy significantly attenuated AL elongation in older children with myopia, with the most pronounced reduction observed in the OKA group (0.03 ± 0.14 mm). Among subjects with higher baseline refractive error, both OKA (0.12 ± 0.13 mm) and SPA (0.16 ± 0.19 mm) groups demonstrated significantly slower AL progression, whereas the HALA (0.12 ± 0.21 mm) cohort exhibited comparatively less effective control of AL growth.

Conclusion

The combination therapy of OK, HAL, or SP with 0.01% atropine significantly slowed myopia progression. Subgroup analysis revealed a differential efficacy: OKA and SPA demonstrated superior control in older children with higher myopia, whereas HALA was more effective in older children with low myopia.