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Background <p>This study aimed to evaluate the incidence and risk factors for early transient intraocular pressure (IOP) elevation after penetrating canaloplasty (PCP) in patients with primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG) and secondary glaucoma (SG).</p> Methods <p>This retrospective study included 198 eyes of 198 patients with glaucoma. Participants were classified as normal IOP, early transient high IOP (E-HIOP [Tst]), early persistent IOP elevation, late transient high IOP, and late persistent IOP elevation, based on the period and persistence of postoperative IOP elevation.</p> Results <p>E-HIOP (Tst) developed in 34.8%, 33.3%, and 40.9% of eyes with POAG, PACG, and SG, respectively. In comparison with normal IOP group, we observed the following variations in E-HIOP (Tst) cohorts: 8 − 10 years younger in patients with POAG and PACG; higher prevalence of hyphema (45.5% vs. 20.5%) in POAG; higher baseline IOP in PACG and SG (7 − 8 mmHg); higher preoperative IOP maximum (IOP<sub>pre−max</sub>) in SG (all <i>p</i> &lt; 0.05). Higher IOP<sub>pre−max</sub> was a risk factor for E-HIOP (Tst) in PACG and SG (<i>p</i> &lt; 0.05).</p> Conclusions <p>Nearly 30 − 40% of eyes developed E-HIOP (Tst) after PCP. E-HIOP (Tst) tended to develop in younger participants and those with higher preoperative IOP. A higher IOP<sub>pre−max</sub> was a risk factor for E-HIOP (Tst) in PACG and SG.</p>

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Incidence and risk factors for early transient intraocular pressure elevation after penetrating canaloplasty in patients with glaucoma

  • 期刊论文

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  • 发表日期：

    2025年10月9日

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  • Lijuan Xu,
  • Juan Gu,
  • Wenqing Ye,
  • Xinyao Zhang,
  • Yin Zhao,
  • Tao Zhou,
  • Jialing Han,
  • Ruiyi Ren,
  • Yuanbo Liang

摘要

Background

This study aimed to evaluate the incidence and risk factors for early transient intraocular pressure (IOP) elevation after penetrating canaloplasty (PCP) in patients with primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG) and secondary glaucoma (SG).

Methods

This retrospective study included 198 eyes of 198 patients with glaucoma. Participants were classified as normal IOP, early transient high IOP (E-HIOP [Tst]), early persistent IOP elevation, late transient high IOP, and late persistent IOP elevation, based on the period and persistence of postoperative IOP elevation.

Results

E-HIOP (Tst) developed in 34.8%, 33.3%, and 40.9% of eyes with POAG, PACG, and SG, respectively. In comparison with normal IOP group, we observed the following variations in E-HIOP (Tst) cohorts: 8 − 10 years younger in patients with POAG and PACG; higher prevalence of hyphema (45.5% vs. 20.5%) in POAG; higher baseline IOP in PACG and SG (7 − 8 mmHg); higher preoperative IOP maximum (IOPpre−max) in SG (all p < 0.05). Higher IOPpre−max was a risk factor for E-HIOP (Tst) in PACG and SG (p < 0.05).

Conclusions

Nearly 30 − 40% of eyes developed E-HIOP (Tst) after PCP. E-HIOP (Tst) tended to develop in younger participants and those with higher preoperative IOP. A higher IOPpre−max was a risk factor for E-HIOP (Tst) in PACG and SG.