Objective <p>To report the efficacy of “Xeno-ADM combined with inferior eyelid margin fixation” for entropion accompanied by lower eyelid retraction.</p> Methods <p>A retrospective review of 28 patients (48 eyes) diagnosed with lower eyelid entropion accompanied by lower eyelid retraction was performed. The follow-up period lasted more than 6&#xa0;months. MRD2, angle between the eyelashes and the corneal surface, ocular discomfort symptoms, and complications were recorded and used to evaluate the efficacy and safety.</p> Results <p>Twenty eight patients (48 eyes) were included, within 6&#xa0;months after surgery, 45 eyes (93.75%) had complete relief from ocular discomfort, while 3 eyes (6.3%) showed partial improvement; 48 eyes (100%) had complete resolution of the foreign body sensation; 15 eyes (83.3%) had complete relief from lacrimation, and 3 eyes (16.7%) showed partial improvement, MRD2 was from 7.2 (7.0, 7.5) mm to 5.5 (5.0, 5.5) mm (Z = -3.995, <i>P</i> &lt; 0.01). The angle between the eyelashes and the cornea was from 36.76 (32.18, 38.49) to 68.23 (67.30, 70.31) (Z = -6.031, <i>P</i> &lt; 0.01). And no other complications, such as infection, rejection, and dislocation, were observed.</p> Conclusion <p>Xeno-ADM combined with inferior eyelid margin fixation is reasonably successful in managing entropion accompanied by lower eyelid retraction.</p>