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<p>Retinopathy of prematurity (ROP) is a preventable cause of childhood blindness in extremely preterm infants, yet early biomarkers are lacking. In this pilot study, we utilized targeted metabolomic profiling of blood samples to measure plasma 6-hydroxymethylpterin (6PTC) levels in 18 preterm neonates. Results showed significantly higher 6PTC levels in infants who developed ROP compared to those who did not (<i>p</i> = 0.035), with receiver-operating characteristic analysis yielding an AUC of 0.831. These findings suggest that 6PTC may serve as a non-invasive early biomarker reflecting oxidative stress in ROP. However, the modest sample size warrants further validation in larger, longitudinal cohorts. Given the limited sample size, these results should be interpreted within the context of a pilot, hypothesis-generating study.</p>

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Early prediction of retinopathy of prematurity using targeted metabolomic profiling of 6-hydroxymethylpterin in preterm infants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月1日

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  • Zeynep Alp Ünkar,
  • Hakan Demir,
  • Bilge Batu Oto,
  • Mehmet Şerif Cansever,
  • Leyla Aliyeva,
  • Atalay Demirel,
  • Ersin Ulu,
  • Uğurcan Sayili,
  • Ayşe Çiğdem Aktuğlu Zeybek,
  • Zekeriyya Mehmet Vural

摘要

Retinopathy of prematurity (ROP) is a preventable cause of childhood blindness in extremely preterm infants, yet early biomarkers are lacking. In this pilot study, we utilized targeted metabolomic profiling of blood samples to measure plasma 6-hydroxymethylpterin (6PTC) levels in 18 preterm neonates. Results showed significantly higher 6PTC levels in infants who developed ROP compared to those who did not (p = 0.035), with receiver-operating characteristic analysis yielding an AUC of 0.831. These findings suggest that 6PTC may serve as a non-invasive early biomarker reflecting oxidative stress in ROP. However, the modest sample size warrants further validation in larger, longitudinal cohorts. Given the limited sample size, these results should be interpreted within the context of a pilot, hypothesis-generating study.