Purpose <p>Dacryoliths located in the temporal canthus were relatively rare. We presented a case of giant ductule dacryolith associated with Haemophilus influenzae and described the clinical features.</p> Case presentation <p>A female patient presented persistent secretion in the lateral canthal region of the right eye. Surgical exploration was performed, and bacterial culture, tissue pathology analysis, and magnetic resonance imaging (MRI) examination were completed. A huge ductule dacryolith was found in the temporal canthus, which was composed of amorphous acidic substances. The bacterial culture results showed infection with Haemophilus influenzae, and the postoperative MRI results showed no signs of inflammation around the lacrimal gland. The patient's symptoms disappeared immediately after the operation.</p> Conclusion <p>Ductule dacryoliths are very rare but worth considering when a patient presents with unilateral lateral refractory conjunctivitis.</p>