Purpose <p>To assess long-term refractive stability and corneal remodelling in patients with moderate to extra-high myopia after the small-incision lenticule extraction (SMILE) surgery.</p> Methods <p>A retrospective analysis of 196 eyes was conducted, categorising them into three groups based on preoperative myopia: Group 1 (moderate myopia, 78 eyes), Group 2 (high myopia, 72 eyes), and Group 3 (extra-high myopia, 46eyes). The predicted and actual values of key parameters, including attempted spherical equivalent (SE), thinnest corneal thickness (TCT), and keratometry (K), were measured and compared 1&#xa0;day and 3 years postoperatively. Correlations were analysed to evaluate refractive stability and corneal changes over time.</p> Results <p>One day postoperatively, the attempted SE correction closely matched the achieved SE in Group 1 (<i>p</i> = 0.225) and 2 (<i>p</i> = 0.235), but was significantly smaller than achieved SE in Group 3 (<i>p</i> = 0.002). At 3 years, Group 3 showed significant undercorrection (<i>p</i> &lt; 0.001) and a greater deviation in predicted versus measured TCT reduction (<i>p</i> &lt; 0.001). Similarly, Group 3 showed significant deviations in flat K values from the expected values at 1&#xa0;day and 3 years (<i>p</i> &lt; 0.0001), indicating greater corneal changes than those in the other groups. Correlation analysis revealed a strong association among preoperative spherical equivalent, postoperative keratometric changes, and long-term refractive outcomes (<i>p</i> &lt; 0.0001).</p> Conclusions <p>SMILE effectively provides short-term refractive correction for all myopia groups. However, long-term refractive stability is less predictable in patients with high myopia due to increased corneal remodelling. Developing personalised, predictive models for these patients could help ensure more stable long-term outcomes.</p>

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Long-term refractive outcomes and corneal remodeling after the SMILE surgery in patients with moderate to extra-high myopia

  • Jing Wang,
  • Xueying Cheng,
  • Weiteng Chang,
  • Xingtao Zhou,
  • Yu Zhao

摘要

Purpose

To assess long-term refractive stability and corneal remodelling in patients with moderate to extra-high myopia after the small-incision lenticule extraction (SMILE) surgery.

Methods

A retrospective analysis of 196 eyes was conducted, categorising them into three groups based on preoperative myopia: Group 1 (moderate myopia, 78 eyes), Group 2 (high myopia, 72 eyes), and Group 3 (extra-high myopia, 46eyes). The predicted and actual values of key parameters, including attempted spherical equivalent (SE), thinnest corneal thickness (TCT), and keratometry (K), were measured and compared 1 day and 3 years postoperatively. Correlations were analysed to evaluate refractive stability and corneal changes over time.

Results

One day postoperatively, the attempted SE correction closely matched the achieved SE in Group 1 (p = 0.225) and 2 (p = 0.235), but was significantly smaller than achieved SE in Group 3 (p = 0.002). At 3 years, Group 3 showed significant undercorrection (p < 0.001) and a greater deviation in predicted versus measured TCT reduction (p < 0.001). Similarly, Group 3 showed significant deviations in flat K values from the expected values at 1 day and 3 years (p < 0.0001), indicating greater corneal changes than those in the other groups. Correlation analysis revealed a strong association among preoperative spherical equivalent, postoperative keratometric changes, and long-term refractive outcomes (p < 0.0001).

Conclusions

SMILE effectively provides short-term refractive correction for all myopia groups. However, long-term refractive stability is less predictable in patients with high myopia due to increased corneal remodelling. Developing personalised, predictive models for these patients could help ensure more stable long-term outcomes.