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Background <p>Orthokeratology (Ortho-K) lenses are increasingly used in children to manage myopia by reshaping the cornea and potentially influencing axial length changes. This study investigated factors affecting axial length changes in children aged 9–17 years wearing Ortho-K lenses, focusing on age, initial spherical value, and other parameters.</p> Methods <p>This retrospective analysis included 84 children (49 males, 35 females, aged 9–17 years) who wore Ortho-K lenses at the Tenth Affiliated Hospital of Southern Medical University between January 2018 and December 2019, with a minimum follow-up of 12 months. Subjects met specific inclusion criteria, including myopia ≤ 6.00 DS and astigmatism ≤ 1.75 DC. Comprehensive ocular examinations were conducted, and axial length changes were measured using an IOL-Master500.</p> Results <p>Univariate analysis revealed significant factors influencing axial length changes, including age (F = -5.476, <i>P</i> &lt; 0.001) and initial equivalent spherical value (F = 8.314, <i>P</i> = 0.004). Mixed-effects model analysis confirmed that the duration of lens wear (mean: 18.3 ± 5.4 months), age, initial spherical lens value, and initial axial length significantly impacted axial length (<i>P</i> &lt; 0.05). The mean axial length elongation was 0.18 ± 0.09&#xa0;mm/year overall, with the low-elongation group showing 0.10 ± 0.05&#xa0;mm/year and the high-elongation group showing 0.27 ± 0.06&#xa0;mm/year. Children with lower initial spherical values and older individuals demonstrated less axial elongation.</p> Conclusion <p>Age and initial equivalent spherical value are critical factors influencing axial length changes in children aged 9–17 years who use Ortho-K lenses. Understanding these factors can enhance the effectiveness of Ortho-K treatment in managing myopia progression. Further studies are needed to optimize lens design and treatment protocols for personalized myopia control.</p>

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Age and initial spherical equivalent influence the axial length elongation in children aged 9–17 years undergoing orthokeratology therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月19日

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  • Guangbin Zhong,
  • Ruinian Zheng,
  • Linyi Luo

摘要

Background

Orthokeratology (Ortho-K) lenses are increasingly used in children to manage myopia by reshaping the cornea and potentially influencing axial length changes. This study investigated factors affecting axial length changes in children aged 9–17 years wearing Ortho-K lenses, focusing on age, initial spherical value, and other parameters.

Methods

This retrospective analysis included 84 children (49 males, 35 females, aged 9–17 years) who wore Ortho-K lenses at the Tenth Affiliated Hospital of Southern Medical University between January 2018 and December 2019, with a minimum follow-up of 12 months. Subjects met specific inclusion criteria, including myopia ≤ 6.00 DS and astigmatism ≤ 1.75 DC. Comprehensive ocular examinations were conducted, and axial length changes were measured using an IOL-Master500.

Results

Univariate analysis revealed significant factors influencing axial length changes, including age (F = -5.476, P < 0.001) and initial equivalent spherical value (F = 8.314, P = 0.004). Mixed-effects model analysis confirmed that the duration of lens wear (mean: 18.3 ± 5.4 months), age, initial spherical lens value, and initial axial length significantly impacted axial length (P < 0.05). The mean axial length elongation was 0.18 ± 0.09 mm/year overall, with the low-elongation group showing 0.10 ± 0.05 mm/year and the high-elongation group showing 0.27 ± 0.06 mm/year. Children with lower initial spherical values and older individuals demonstrated less axial elongation.

Conclusion

Age and initial equivalent spherical value are critical factors influencing axial length changes in children aged 9–17 years who use Ortho-K lenses. Understanding these factors can enhance the effectiveness of Ortho-K treatment in managing myopia progression. Further studies are needed to optimize lens design and treatment protocols for personalized myopia control.