Scholarlink

Background <p>Large, unresectable hepatocellular carcinoma (HCC) remains incurable, and the risk of radiation-induced liver damage makes definitive radiotherapy challenging. We aimed to evaluate the efficacy and safety of carbon-ion radiotherapy (CIRT).</p> Methods <p>We retrospectively analyzed records of 33 CIRT-treated patients with HCC (diameter ≥ 10&#xa0;cm) at Osaka Heavy Ion Therapy Center. Rates of local control (LC), progression-free survival (PFS), and overall survival (OS) were calculated using the Kaplan–Meier method. Toxicities were evaluated according to the Common Terminology Criteria for Adverse Events v5.0.</p> Results <p>The median tumor diameter was 11 (range: 10–18) cm. Stage IB was the most common disease stage, and alcoholic liver disease was the most common underlying condition. The relative biological effectiveness-weighted dose was 60&#xa0;Gy/4 fractions, 67.2&#xa0;Gy/12 fractions, and 60&#xa0;Gy/12 fractions in 19, 8, and 6 patients, respectively. Based on pretreatment liver function, 27 and 6 patients were categorized as Child–Pugh classes A and B, respectively. The median follow-up period was 15.1 (range: 2.8–54.0) months. The 1-year LC, PFS, and OS rates were 85.9%, 30.0%, and 74.8%, respectively. Grade ≥ 3 toxicities included pleural effusion in two patients (6%) and hepatic failure, heart failure, bile duct stricture, and biliary tract infection in one patient (3%) each. No grade ≥ 4 toxicities occurred. Radiation-induced liver damage, defined as a Child–Pugh score increase ≥ 2 points from the pretreatment baseline, occurred in five patients (15%).</p> Conclusions <p>CIRT for large HCC (≥ 10&#xa0;cm) was effective in the short term, with acceptable toxicities. However, the short follow-up may have led to an underestimation of the incidence of late complications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Efficacy and safety of carbon-ion radiotherapy for large hepatocellular carcinoma (diameter ≥ 10 cm)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月25日

查看全文
  • Kazuhiko Hayashi,
  • Osamu Suzuki,
  • Koji Ichise,
  • Hirofumi Uchida,
  • Fumiko Nagano,
  • Azusa Hasegawa,
  • Shinichi Shimizu,
  • Jiro Fujimoto,
  • Kazuhiko Ogawa

摘要

Background

Large, unresectable hepatocellular carcinoma (HCC) remains incurable, and the risk of radiation-induced liver damage makes definitive radiotherapy challenging. We aimed to evaluate the efficacy and safety of carbon-ion radiotherapy (CIRT).

Methods

We retrospectively analyzed records of 33 CIRT-treated patients with HCC (diameter ≥ 10 cm) at Osaka Heavy Ion Therapy Center. Rates of local control (LC), progression-free survival (PFS), and overall survival (OS) were calculated using the Kaplan–Meier method. Toxicities were evaluated according to the Common Terminology Criteria for Adverse Events v5.0.

Results

The median tumor diameter was 11 (range: 10–18) cm. Stage IB was the most common disease stage, and alcoholic liver disease was the most common underlying condition. The relative biological effectiveness-weighted dose was 60 Gy/4 fractions, 67.2 Gy/12 fractions, and 60 Gy/12 fractions in 19, 8, and 6 patients, respectively. Based on pretreatment liver function, 27 and 6 patients were categorized as Child–Pugh classes A and B, respectively. The median follow-up period was 15.1 (range: 2.8–54.0) months. The 1-year LC, PFS, and OS rates were 85.9%, 30.0%, and 74.8%, respectively. Grade ≥ 3 toxicities included pleural effusion in two patients (6%) and hepatic failure, heart failure, bile duct stricture, and biliary tract infection in one patient (3%) each. No grade ≥ 4 toxicities occurred. Radiation-induced liver damage, defined as a Child–Pugh score increase ≥ 2 points from the pretreatment baseline, occurred in five patients (15%).

Conclusions

CIRT for large HCC (≥ 10 cm) was effective in the short term, with acceptable toxicities. However, the short follow-up may have led to an underestimation of the incidence of late complications.