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<p>The reader noted that a deep hypoechoic area is the main echoic indication of subserosa (SS) invasion of malignant gallbladder tumors. In this study, we evaluated an irregular lateral high-echoic layer (LHEL) as the main indication of SS invasion. If the presence of a deep hypoechoic area combined with an irregular LHEL is considered, the diagnosis of SS invasion may be improved.</p>

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Reply to “Matters Arising: a simple method for diagnosing gallbladder malignant tumors with subserosa invasion by endoscopic ultrasonography”

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月5日

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  • Mitsuru Sugimoto,
  • Tadayuki Takagi,
  • Hiromasa Ohira

摘要

The reader noted that a deep hypoechoic area is the main echoic indication of subserosa (SS) invasion of malignant gallbladder tumors. In this study, we evaluated an irregular lateral high-echoic layer (LHEL) as the main indication of SS invasion. If the presence of a deep hypoechoic area combined with an irregular LHEL is considered, the diagnosis of SS invasion may be improved.