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Background <p>Gastric cancer (GC) remains a significant cause of mortality worldwide. Exploring the pathogenesis of GC is crucial for developing new therapeutic strategies.</p> Methods <p>Clinical sample sequencing and immunohistochemical analyses were employed to investigate the expression patterns of solute carrier organic anion transporter B3 (SLCO1B3) in GC and surrounding normal tissues, as well as its effect on GC prognosis. In vitro GC studies were performed to confirm the effects of SLCO1B3 overexpression and knockdown on GC cell proliferation, migration, and invasion, as well as the influence of SLCO1B3 overexpression on carcinogenesis in vivo. Furthermore, RNA sequencing of gastric cancer cells overexpressing SLCO1B3 revealed microtubule-associated protein 1&#xa0;S (MAP1S) as a potential downstream target, suggesting SLCO1B3 may promote gastric cancer progression by regulating MAP1S expression.</p> Conclusion <p>SLCO1B3 expression is elevated in GC versus adjacent tissues and correlates with diminished patient survival rates. Overexpression of Ct-SLCO1B3 may be associated with downregulation of MAP1S, suggesting that Ct-SLCO1B3 may promote gastric cancer development and metastasis by regulating its expression.</p>

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A mechanistic study revealing that SLCO1B3 promotes gastric cancer development and metastasis through MAP1S expression downregulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月29日

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  • Shihao Liang,
  • Yangyuan Huang,
  • Liping Li,
  • Qingyu Zeng,
  • Wenjie Liao,
  • Weiyan Li,
  • Leiyu Qin,
  • Bin Li

摘要

Background

Gastric cancer (GC) remains a significant cause of mortality worldwide. Exploring the pathogenesis of GC is crucial for developing new therapeutic strategies.

Methods

Clinical sample sequencing and immunohistochemical analyses were employed to investigate the expression patterns of solute carrier organic anion transporter B3 (SLCO1B3) in GC and surrounding normal tissues, as well as its effect on GC prognosis. In vitro GC studies were performed to confirm the effects of SLCO1B3 overexpression and knockdown on GC cell proliferation, migration, and invasion, as well as the influence of SLCO1B3 overexpression on carcinogenesis in vivo. Furthermore, RNA sequencing of gastric cancer cells overexpressing SLCO1B3 revealed microtubule-associated protein 1 S (MAP1S) as a potential downstream target, suggesting SLCO1B3 may promote gastric cancer progression by regulating MAP1S expression.

Conclusion

SLCO1B3 expression is elevated in GC versus adjacent tissues and correlates with diminished patient survival rates. Overexpression of Ct-SLCO1B3 may be associated with downregulation of MAP1S, suggesting that Ct-SLCO1B3 may promote gastric cancer development and metastasis by regulating its expression.