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Background <p>Although transarterial chemoembolization (TACE) has been widely used to treat malignant cholangiocarcinoma (CCA), the efficacy of drug-loaded microsphere chemoembolization (DEB-TACE) remains to be comprehensively explored in patients with CCA combined with obstructive jaundice.</p> Methods <p>In this single-center retrospective cohort study, patients (<i>n</i> = 101) with CCA combined with obstructive jaundice admitted between January 2021 and December 2022 were treated with DEB-TACE or c-TACE. Initially, the baseline characteristics of the two groups of patients, i.e., DEB-TACE (<i>n</i> = 46) and c-TACE (<i>n</i> = 55), were estimated. Further, the survival time was analyzed using the Kaplan-Meier (KM) method, exploring independent risk factors affecting patients’ survival time by the Cox proportional risk model.</p> Results <p>The DEB-TACE group showed a significantly better imaging efficacy than the c-TACE group, with an objective remission rate (ORR) of 47.8% vs. 0.0% and a disease control rate (DCR) of 95.7% vs. 70.9% (<i>P</i> &lt; 0.001). The survival analysis showed a higher median overall survival (OS) time of 14 months and a 1-year survival rate of 70.7% in the DEB-TACE group than 11 months and 0.0% in the c-TACE group (<i>P</i> &lt; 0.001), respectively. The Cox regression analysis showed the DEB-TACE treatment as an independent protective factor for prolonged OS (HR = 0.072, <i>P</i> &lt; 0.001).</p> Conclusion <p>Despite the low long-term survival rates in both groups, DEB-TACE, as an effective local therapy, could provide an important reference for optimizing the treatment of advanced CCA.</p>

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Effectiveness of transarterial drug-loaded microsphere chemoembolization against cholangiocarcinoma combined with obstructive jaundice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月6日

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  • Baoyang Jia,
  • Yongli Chen,
  • Rui Lin,
  • Junhui Yang,
  • Xinyue Meng,
  • Xiaoming Meng

摘要

Background

Although transarterial chemoembolization (TACE) has been widely used to treat malignant cholangiocarcinoma (CCA), the efficacy of drug-loaded microsphere chemoembolization (DEB-TACE) remains to be comprehensively explored in patients with CCA combined with obstructive jaundice.

Methods

In this single-center retrospective cohort study, patients (n = 101) with CCA combined with obstructive jaundice admitted between January 2021 and December 2022 were treated with DEB-TACE or c-TACE. Initially, the baseline characteristics of the two groups of patients, i.e., DEB-TACE (n = 46) and c-TACE (n = 55), were estimated. Further, the survival time was analyzed using the Kaplan-Meier (KM) method, exploring independent risk factors affecting patients’ survival time by the Cox proportional risk model.

Results

The DEB-TACE group showed a significantly better imaging efficacy than the c-TACE group, with an objective remission rate (ORR) of 47.8% vs. 0.0% and a disease control rate (DCR) of 95.7% vs. 70.9% (P < 0.001). The survival analysis showed a higher median overall survival (OS) time of 14 months and a 1-year survival rate of 70.7% in the DEB-TACE group than 11 months and 0.0% in the c-TACE group (P < 0.001), respectively. The Cox regression analysis showed the DEB-TACE treatment as an independent protective factor for prolonged OS (HR = 0.072, P < 0.001).

Conclusion

Despite the low long-term survival rates in both groups, DEB-TACE, as an effective local therapy, could provide an important reference for optimizing the treatment of advanced CCA.