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Background <p>Early detection of micrometastatic disease in endometrial carcinoma (EC) remains a major clinical challenge. This study evaluated Migration Inducing Gene 7 (MIG7) and Trefoil Factor Family 3 (TFF3) as minimally invasive biomarkers for EC progression.</p> Methods <p>MIG7 and TFF3 gene expression and circulating TFF3 protein levels were analyzed in 75 subjects: healthy controls (<i>n</i> = 25), non-metastatic EC (<i>n</i> = 25), and metastatic EC (<i>n</i> = 25). Diagnostic performance was assessed using ROC analysis and logistic regression.</p> Results <p>A significant stepwise increase was observed from controls to metastatic EC in MIG7 expression (0.69 vs. 1.97), TFF3 expression (0.38 vs. 2.03), and TFF3 protein levels (0.41 vs. 6.09; <i>P</i> &lt; 0.001). Diagnostic accuracy was high, with AUC values of 0.945, 0.998, and 0.999, respectively. TFF3 gene expression showed the highest balanced performance (96% sensitivity, 100% specificity). MIG7 and TFF3 expression were strongly correlated (<i>r</i> = 0.818, <i>P</i> &lt; 0.001). All markers independently predicted metastatic disease (<i>P</i> &lt; 0.05).</p> Conclusion <p>MIG7 and TFF3 are robust minimally invasive biomarkers for EC detection and metastatic risk stratification.</p>

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Trefoil factor family 3 (TFF3) and migration inducting gene 7 (MIG7) as molecular markers for early detection of endometrial carcinoma micro metastases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月26日

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  • Dina Aly Abdelaziz,
  • Amal K. Seleem,
  • Abdel Aziz A. El Refaeey,
  • Lamiaa A. Barakat,
  • Mohamed M. Tawfik

摘要

Background

Early detection of micrometastatic disease in endometrial carcinoma (EC) remains a major clinical challenge. This study evaluated Migration Inducing Gene 7 (MIG7) and Trefoil Factor Family 3 (TFF3) as minimally invasive biomarkers for EC progression.

Methods

MIG7 and TFF3 gene expression and circulating TFF3 protein levels were analyzed in 75 subjects: healthy controls (n = 25), non-metastatic EC (n = 25), and metastatic EC (n = 25). Diagnostic performance was assessed using ROC analysis and logistic regression.

Results

A significant stepwise increase was observed from controls to metastatic EC in MIG7 expression (0.69 vs. 1.97), TFF3 expression (0.38 vs. 2.03), and TFF3 protein levels (0.41 vs. 6.09; P < 0.001). Diagnostic accuracy was high, with AUC values of 0.945, 0.998, and 0.999, respectively. TFF3 gene expression showed the highest balanced performance (96% sensitivity, 100% specificity). MIG7 and TFF3 expression were strongly correlated (r = 0.818, P < 0.001). All markers independently predicted metastatic disease (P < 0.05).

Conclusion

MIG7 and TFF3 are robust minimally invasive biomarkers for EC detection and metastatic risk stratification.