Background Online adaptive radiotherapy (oART) can provide dosimetric advantages by accounting for daily anatomic changes, potentially improving target coverage and sparing of organs at risk. However, clinical adoption is sometimes limited by concerns over increased per-session treatment time. In this single-center study, we present 1.5 years of clinical experience focused on reducing the oART session time for prostate cancer patients. Methods We analyzed 1366 oART sessions from 69 prostate cancer patients treated on a Varian Ethos system between July 2023 and December 2024. We recorded (i) total session time — time between patient entry and exit from the treatment room, and (ii) adaptation time — time from start of the daily cone-beam-CT acquisition to completion of contour review/correction. We assessed the effects of two time-saving measures: automated contouring of the posterior rectal wall and installation of Varian HyperSight imaging. Statistical comparisons used the Mann–Whitney U test. Results Automated posterior rectal wall contouring decreased mean adaptation time from 16.0 to 10.5 min (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(p<0.001\)</EquationSource> </InlineEquation>). Installation of HyperSight reduced mean total session time from 25.8 to 23.3 min (<InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(p<0.001\)</EquationSource> </InlineEquation>); the adaptation component improved by 0.5 min but not statistically significant (<InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(p=0.053\)</EquationSource> </InlineEquation>). We achieved a total session time of <InlineEquation ID="IEq4"> <EquationSource Format="TEX">\(\leqslant 30\)</EquationSource> </InlineEquation> min for 93% of sessions. Conclusions Cone-beam-CT-guided oART is feasible in routine prostate cancer practice. Our findings indicate that a 30-minute time slot is sufficient for most adaptive prostate cancer treatments, and a median total session time of 23 minutes can be reached through workflow and imaging optimization. Clinics considering oART should note that treatment time decreases with operator experience, and targeted measures can further reduce session duration.

Clinical experience with an online adaptive radiotherapy for prostate cancer: successful treatment time optimization

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2026年2月19日

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Hanna Malygina,
Bryan Salazar Zuniga,
Hendrik Auerbach,
Marc Ries,
Sven Knobe,
Yvonne Dzierma,
Jan Palm,
Markus Hecht

摘要

Background

Online adaptive radiotherapy (oART) can provide dosimetric advantages by accounting for daily anatomic changes, potentially improving target coverage and sparing of organs at risk. However, clinical adoption is sometimes limited by concerns over increased per-session treatment time. In this single-center study, we present 1.5 years of clinical experience focused on reducing the oART session time for prostate cancer patients.

Methods

We analyzed 1366 oART sessions from 69 prostate cancer patients treated on a Varian Ethos system between July 2023 and December 2024. We recorded (i) total session time — time between patient entry and exit from the treatment room, and (ii) adaptation time — time from start of the daily cone-beam-CT acquisition to completion of contour review/correction. We assessed the effects of two time-saving measures: automated contouring of the posterior rectal wall and installation of Varian HyperSight imaging. Statistical comparisons used the Mann–Whitney U test.

Results

Automated posterior rectal wall contouring decreased mean adaptation time from 16.0 to 10.5 min ( \(p<0.001\) ). Installation of HyperSight reduced mean total session time from 25.8 to 23.3 min ( \(p<0.001\) ); the adaptation component improved by 0.5 min but not statistically significant ( \(p=0.053\) ). We achieved a total session time of \(\leqslant 30\) min for 93% of sessions.

Conclusions

Cone-beam-CT-guided oART is feasible in routine prostate cancer practice. Our findings indicate that a 30-minute time slot is sufficient for most adaptive prostate cancer treatments, and a median total session time of 23 minutes can be reached through workflow and imaging optimization. Clinics considering oART should note that treatment time decreases with operator experience, and targeted measures can further reduce session duration.