Scholarlink

Background <p>While various modifiable risk factors for the incidence of early-onset breast cancer (EOBC) have been identified, their association with breast cancer-specific mortality (BCSM) among patients is not well known.</p> Methods <p>To assess the association between modifiable factors and breast cancer-specific mortality, we estimated hazard ratios (HRs) for BCSM in relation to these factors in a cohort of 53,899 women with 380 EOBC (aged 18–49 years at diagnosis) cases and 77 EOBC-related deaths by using the Cox proportional hazards regression.</p> Results <p>Pre-diagnosis BMI &gt; 25&#xa0;kg/m<sup>2</sup> was associated with an increased risk of BCSM (HR 1.85, 95% CI 1.04–3.30) compared to normal weight women.</p> Conclusions <p>Being overweight or obese before an early-onset breast cancer diagnosis is associated with increased breast cancer-specific mortality. Although the potential underlying biological mechanisms remain inconclusive, it likely involves complex hormonal alterations related to changes in body adiposity. As voluntary weight loss is generally not advised during cancer treatment, maintaining a healthy weight throughout adulthood is strongly encouraged to reduce numerous health risks, including excess mortality in young breast cancer patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Associations between modifiable factors and early-onset breast cancer mortality among patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月29日

查看全文
  • Jasmiina Rantala,
  • Karri Seppä,
  • Johan Eriksson,
  • Sirpa Heinävaara,
  • Tommi Härkänen,
  • Pekka Jousilahti,
  • Paul Knekt,
  • Seppo Koskinen,
  • Maarit Laaksonen,
  • Nea Malila,
  • Satu Männistö,
  • Ossi Rahkonen,
  • Heidi Ryynänen,
  • Sanna Lappi-Heikkinen,
  • Janne Pitkäniemi

摘要

Background

While various modifiable risk factors for the incidence of early-onset breast cancer (EOBC) have been identified, their association with breast cancer-specific mortality (BCSM) among patients is not well known.

Methods

To assess the association between modifiable factors and breast cancer-specific mortality, we estimated hazard ratios (HRs) for BCSM in relation to these factors in a cohort of 53,899 women with 380 EOBC (aged 18–49 years at diagnosis) cases and 77 EOBC-related deaths by using the Cox proportional hazards regression.

Results

Pre-diagnosis BMI > 25 kg/m2 was associated with an increased risk of BCSM (HR 1.85, 95% CI 1.04–3.30) compared to normal weight women.

Conclusions

Being overweight or obese before an early-onset breast cancer diagnosis is associated with increased breast cancer-specific mortality. Although the potential underlying biological mechanisms remain inconclusive, it likely involves complex hormonal alterations related to changes in body adiposity. As voluntary weight loss is generally not advised during cancer treatment, maintaining a healthy weight throughout adulthood is strongly encouraged to reduce numerous health risks, including excess mortality in young breast cancer patients.