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Background <p>Despite the favorable prognosis of patients with pathological stage I gastric cancer (GC), recurrence may occur in a subset of individuals, and the underlying risk factors are currently being investigated. Tumor index (TI) plays a valuable role in predicting the prognosis of GC. The study aimed to determine the prognostic effect of TI on stage Ⅰ GC.</p> Methods <p>Patients with stage Ⅰ GC who underwent radical resection were enrolled from the two medical centers from 2010 to 2020. TI was calculated by the pathological T stage multiplied by the maximum tumor diameter. The primary outcome was disease-free survival (DFS) and overall survival (OS). Cox regression analyses were utilized to evaluate the correlation between TI and prognosis.</p> Results <p>The final analysis included a total of 684 patients from two medical centers. Higher TI exhibited a significant correlation with several clinicopathologic features, including N0 stage, TNM stage ⅠB, and positive PNI (all <i>P</i> &lt; 0.05). Patients with high TI showed inferior DFS and OS compared to those with a low TI (<i>P</i> &lt; 0.05). Multivariate analysis revealed that TI was an independent prognostic factor for DFS (hazard ratio (HR) = 2.44, <i>P</i> = 0.010) and OS (HR = 2.39, <i>P</i> = 0.014) in patients with stage Ⅰ GC who underwent radical resection.</p> Conclusion <p>TI was an independent risk factor in recurrence and overall survival for stage Ⅰ GC patients who received curative gastrectomy. Incorporation of TI into clinical decision-making regarding adjuvant therapy and intensity of follow-up may be warranted.</p>

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Tumor index predicts recurrences of patients with pathological stage Ⅰ gastric cancer after radical surgical resection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月7日

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  • Yijia Lin,
  • Huaxian Chen,
  • Chengzhi Wei,
  • Dandong Luo,
  • Jianping Guo,
  • Xiansheng Hu,
  • Yinghan Chen,
  • Junsheng Peng,
  • Yongming Chen,
  • Lei Lian

摘要

Background

Despite the favorable prognosis of patients with pathological stage I gastric cancer (GC), recurrence may occur in a subset of individuals, and the underlying risk factors are currently being investigated. Tumor index (TI) plays a valuable role in predicting the prognosis of GC. The study aimed to determine the prognostic effect of TI on stage Ⅰ GC.

Methods

Patients with stage Ⅰ GC who underwent radical resection were enrolled from the two medical centers from 2010 to 2020. TI was calculated by the pathological T stage multiplied by the maximum tumor diameter. The primary outcome was disease-free survival (DFS) and overall survival (OS). Cox regression analyses were utilized to evaluate the correlation between TI and prognosis.

Results

The final analysis included a total of 684 patients from two medical centers. Higher TI exhibited a significant correlation with several clinicopathologic features, including N0 stage, TNM stage ⅠB, and positive PNI (all P < 0.05). Patients with high TI showed inferior DFS and OS compared to those with a low TI (P < 0.05). Multivariate analysis revealed that TI was an independent prognostic factor for DFS (hazard ratio (HR) = 2.44, P = 0.010) and OS (HR = 2.39, P = 0.014) in patients with stage Ⅰ GC who underwent radical resection.

Conclusion

TI was an independent risk factor in recurrence and overall survival for stage Ⅰ GC patients who received curative gastrectomy. Incorporation of TI into clinical decision-making regarding adjuvant therapy and intensity of follow-up may be warranted.