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Purpose <p>To provide real-world evidence of the clinical characteristics and outcomes of localized and locally advanced prostate cancer patients (LPC/LAPC).</p> Materials &amp; methods <p>Observational and retrospective analysis using secondary data from electronic health records (EHR) of prostate cancer (PC) patients in eight Spanish hospitals (2014–2018). Data was extracted and analyzed using EHRead® technology, based on natural language processing and machine learning. LPC/LAPC patients were included and stratified by risk and by first treatment received.</p> Results <p>Twenty-two thousand one hundred sixty-six PC patients were identified,14,434 (65.1%) were classified as LPC/LAPC. Among them, 5,331 incident patients with sufficient data were selected for outcome analysis (real world overall survival [rwOS], metastasis and event free survival [MFS, EFS]) and were followed for a median time of 2.3 years. 36.5% were classified as LPC intermediate risk (IR), 26.0% LPC high risk (HR), 7.3% LPC low risk (LR), 5.9% LAPC, and 24.2% unknown risk. First treatment received was radiotherapy (RT) in 40.7%, radical prostatectomy (RP) in 37.1%, active surveillance (AS)/watchful waiting (WW) in 6.4%, brachytherapy (BT) in 4.2%, and androgen deprivation therapy monotherapy (ADT only) in 3.3%. rwOS and MFS worsened as risk increased. Patients treated with ADT only presented the worst baseline characteristics, showing limited clinical outcomes. The 36-month rwOS was 91% for LAPC patients, 93% for HR-LPC, 97% for IR-LPC, and 98% for LR-LPC.</p> Conclusions <p>Despite using treatment with curative intent, patients experienced oncological events within a median of less than three years post-diagnosis. Our findings emphasize the need for risk stratification, and proactive strategies to improve clinical outcomes.</p>

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Real-world evidence in localized and locally advanced prostate cancer: applying artificial intelligence to electronic health records

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月21日

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  • José Pablo Maroto,
  • Javier Puente,
  • Antonio Conde Moreno,
  • Álvaro Juárez,
  • Beatriz Garcillán,
  • José Miguel Calderón,
  • Jacobo Muñoz del Toro,
  • Juan Luis Valdivieso,
  • María López-Menduiña,
  • Eduard Sarró,
  • Antonio Alcaraz

摘要

Purpose

To provide real-world evidence of the clinical characteristics and outcomes of localized and locally advanced prostate cancer patients (LPC/LAPC).

Materials & methods

Observational and retrospective analysis using secondary data from electronic health records (EHR) of prostate cancer (PC) patients in eight Spanish hospitals (2014–2018). Data was extracted and analyzed using EHRead® technology, based on natural language processing and machine learning. LPC/LAPC patients were included and stratified by risk and by first treatment received.

Results

Twenty-two thousand one hundred sixty-six PC patients were identified,14,434 (65.1%) were classified as LPC/LAPC. Among them, 5,331 incident patients with sufficient data were selected for outcome analysis (real world overall survival [rwOS], metastasis and event free survival [MFS, EFS]) and were followed for a median time of 2.3 years. 36.5% were classified as LPC intermediate risk (IR), 26.0% LPC high risk (HR), 7.3% LPC low risk (LR), 5.9% LAPC, and 24.2% unknown risk. First treatment received was radiotherapy (RT) in 40.7%, radical prostatectomy (RP) in 37.1%, active surveillance (AS)/watchful waiting (WW) in 6.4%, brachytherapy (BT) in 4.2%, and androgen deprivation therapy monotherapy (ADT only) in 3.3%. rwOS and MFS worsened as risk increased. Patients treated with ADT only presented the worst baseline characteristics, showing limited clinical outcomes. The 36-month rwOS was 91% for LAPC patients, 93% for HR-LPC, 97% for IR-LPC, and 98% for LR-LPC.

Conclusions

Despite using treatment with curative intent, patients experienced oncological events within a median of less than three years post-diagnosis. Our findings emphasize the need for risk stratification, and proactive strategies to improve clinical outcomes.