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Objectives <p>To evaluate the value of amide-proton-transfer weighted (APTw) imaging in differentiating pediatric low-grade gliomas (pLGG) and high-grade gliomas (pHGG).</p> Materials and methods <p>In this retrospective study, APTw imaging from 69 consecutive pediatric patients suspected of brain tumors from April 2021 to March 2024 were reviewed for possible inclusion. Histogram metrics of APTw imaging for the gross tumor core and solid components were extracted. Student’s t-test or Mann-Whitney U test was used to compare histogram metrics between pLGG and pHGG. Receiver operating characteristic curve with area under the curve (AUC) was generated for statistically significant histogram metrics. A Bonferroni correction was applied for <i>p</i> value for 10 APTw metrics (<i>p</i> &lt; 0.005 was considered significant).</p> Results <p>Thirty-two patients (mean age: 68 ± 39 months; 18 males, 16 females) were included in the final analysis. The gross tumor core of pLGG exhibited higher APT<sub>min</sub> (<i>p</i> = 0.017), and lower variance (<i>p</i> = 0.041) compared to pHGG. The solid components of pHGG had higher APT<sub>max</sub> (<i>p</i> = 0.02), variance (<i>p</i> = 0.02), entropy (<i>p</i> = 0.02) but lower APT<sub>min</sub> (<i>p</i> = 0.03) compared to pLGG. For the gross tumor core, pilocytic astrocytoma had significantly higher APT 10th than pHGG (<i>p</i> = 0.003). The AUC for APT 10th to differentiating pilocytic astrocytoma and pHGG was 0.82.</p> Conclusions <p>Volumetric tumor APT histogram analysis may serve as a potential tool for differentiating pLGG and pHGG, but its application is different from adult population.</p>

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Volumetric amide-proton-transfer weighted imaging histogram analysis to differentiate pediatric high-grade and low-grade gliomas

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月28日

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  • Guisen Lin,
  • Yijiang Zhuang,
  • Feifei Lin,
  • Weiting Tan,
  • Shijie Hu,
  • Dongxia Mo,
  • Hairui Xiong,
  • Hongwu Zeng

摘要

Objectives

To evaluate the value of amide-proton-transfer weighted (APTw) imaging in differentiating pediatric low-grade gliomas (pLGG) and high-grade gliomas (pHGG).

Materials and methods

In this retrospective study, APTw imaging from 69 consecutive pediatric patients suspected of brain tumors from April 2021 to March 2024 were reviewed for possible inclusion. Histogram metrics of APTw imaging for the gross tumor core and solid components were extracted. Student’s t-test or Mann-Whitney U test was used to compare histogram metrics between pLGG and pHGG. Receiver operating characteristic curve with area under the curve (AUC) was generated for statistically significant histogram metrics. A Bonferroni correction was applied for p value for 10 APTw metrics (p < 0.005 was considered significant).

Results

Thirty-two patients (mean age: 68 ± 39 months; 18 males, 16 females) were included in the final analysis. The gross tumor core of pLGG exhibited higher APTmin (p = 0.017), and lower variance (p = 0.041) compared to pHGG. The solid components of pHGG had higher APTmax (p = 0.02), variance (p = 0.02), entropy (p = 0.02) but lower APTmin (p = 0.03) compared to pLGG. For the gross tumor core, pilocytic astrocytoma had significantly higher APT 10th than pHGG (p = 0.003). The AUC for APT 10th to differentiating pilocytic astrocytoma and pHGG was 0.82.

Conclusions

Volumetric tumor APT histogram analysis may serve as a potential tool for differentiating pLGG and pHGG, but its application is different from adult population.