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Background <p>The effectiveness of whole brain radiation therapy with simultaneous integrated boost (WBRT-SIB) in comparison to whole brain radiation therapy alone (WBRT-alone) is yet unknown, despite the fact that its use in clinic is growing. To investigate the variations in intracranial control and overall survival (OS) between the two approaches, we conducted a matching comparison for patients with brain metastases (BM).</p> Method <p>From January 1, 2015, to December 31, 2019, a total of 245 BM patients were eligible for inclusion, including 154 patients who received WBRT-alone (30&#xa0;Gy/10 fractions) and 91 patients who received WBRT-SIB (40–50&#xa0;Gy/10 fractions). 1:1 propensity score matching was used to select the patients with balanced baseline characteristics. The intracranial control and OS condition were analyzed using Kaplan-Meier method, Log-rank test, and Cox proportional hazard regression model.</p> Results <p>138 patients were matched into the WBRT-SIB group and the WBRT-alone group. Of these, 113 (81.9%) patients had BM originating from the lungs, and 124 (89.9%) patients had more than 3 intracranial lesions. After the initiation of radiotherapy, the WBRT-SIB group and the WBRT-alone group had respective 2-year intracranial progression-free survival (iPFS), local progression-free survival (iLPFS), and distant progression-free survival (iDPFS) of 46.2% and 24.5% (<i>p</i> = 0.017), 49.4% and 29.8% (<i>p</i> = 0.033), and 68.6% and 54.4% (<i>p</i> = 0.040). There was no significant difference in OS (22.2 vs. 19.0 months, <i>p</i> = 0.768). However, in the exploratory subgroup analysis of infratentorial with/without supratentorial metastases (<i>n</i> = 96), the WBRT-SIB group showed a significantly better OS than the WBRT-alone group (24.6 vs.17.2 months, <i>p</i> = 0.040). Furthermore, the Cox proportional hazard model of this subgroup revealed that WBRT-SIB (<i>p</i> = 0.039) and systemic therapy after radiotherapy (<i>p</i> = 0.002) were independent prognostic factors for OS. There was no difference in the incidence of grade 3–4 acute brain radiation reactions between the two groups (24.6% vs. 17.4%, <i>p</i> = 0.290).</p> Conclusion <p>WBRT-SIB is a promising strategy for patients with BM. Compared to WBRT alone, WBRT-SIB can significantly prolong the intracranial PFS (including local and distant PFS). Additionally, while WBRT-SIB did not improve OS in the entire cohort, the OS benefit for patients with BM accompanied by infratentorial involvement warrants further exploration.</p>

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A retrospective propensity-matched study comparing whole-brain radiotherapy with simultaneous integrated boost to whole-brain radiotherapy alone for brain metastases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Zheqing Liu,
  • Xiaojing Du,
  • Meiling Deng,
  • Yuanyuan Chen,
  • Shaoxiong Wu

摘要

Background

The effectiveness of whole brain radiation therapy with simultaneous integrated boost (WBRT-SIB) in comparison to whole brain radiation therapy alone (WBRT-alone) is yet unknown, despite the fact that its use in clinic is growing. To investigate the variations in intracranial control and overall survival (OS) between the two approaches, we conducted a matching comparison for patients with brain metastases (BM).

Method

From January 1, 2015, to December 31, 2019, a total of 245 BM patients were eligible for inclusion, including 154 patients who received WBRT-alone (30 Gy/10 fractions) and 91 patients who received WBRT-SIB (40–50 Gy/10 fractions). 1:1 propensity score matching was used to select the patients with balanced baseline characteristics. The intracranial control and OS condition were analyzed using Kaplan-Meier method, Log-rank test, and Cox proportional hazard regression model.

Results

138 patients were matched into the WBRT-SIB group and the WBRT-alone group. Of these, 113 (81.9%) patients had BM originating from the lungs, and 124 (89.9%) patients had more than 3 intracranial lesions. After the initiation of radiotherapy, the WBRT-SIB group and the WBRT-alone group had respective 2-year intracranial progression-free survival (iPFS), local progression-free survival (iLPFS), and distant progression-free survival (iDPFS) of 46.2% and 24.5% (p = 0.017), 49.4% and 29.8% (p = 0.033), and 68.6% and 54.4% (p = 0.040). There was no significant difference in OS (22.2 vs. 19.0 months, p = 0.768). However, in the exploratory subgroup analysis of infratentorial with/without supratentorial metastases (n = 96), the WBRT-SIB group showed a significantly better OS than the WBRT-alone group (24.6 vs.17.2 months, p = 0.040). Furthermore, the Cox proportional hazard model of this subgroup revealed that WBRT-SIB (p = 0.039) and systemic therapy after radiotherapy (p = 0.002) were independent prognostic factors for OS. There was no difference in the incidence of grade 3–4 acute brain radiation reactions between the two groups (24.6% vs. 17.4%, p = 0.290).

Conclusion

WBRT-SIB is a promising strategy for patients with BM. Compared to WBRT alone, WBRT-SIB can significantly prolong the intracranial PFS (including local and distant PFS). Additionally, while WBRT-SIB did not improve OS in the entire cohort, the OS benefit for patients with BM accompanied by infratentorial involvement warrants further exploration.