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Aim <p>The aim of this study is to interrogate the gross histopathological patterns, correlation between histological type with tumor location, treatment, and complications of patients with ameloblastomas seen at Khartoum Teaching Dental Hospital.</p> Method <p>This was a cross-sectional retrospective laboratory-based study using 390 patients identified histologically with ameloblastoma between the years 2010–2017. Information regarding age, gender, histopathologic type, anatomical site, tumour size, clinical and radiographic data as well as biological features of the types of ameloblastoma was obtained from laboratory demand outlines. Categorical and continuous variables were summarized in percentage and mean ± standard deviation, respectively. Continuous and categorical variables were summarized using mean ± standard deviation (SD) and percentages, respectively. Sociodemographic characteristics and healthcare-related variables were compared using the chi-square test, while economic status was analyzed using Duncan’s multiple range test.</p> Results <p>A total of 390 patients of ameloblastoma were included with a mean patient age of 30.74 ± 5.21 years (range: 9–68 years), male to female ratio of patients was 1.3:1. Maximum of approximately 68.46% (<i>n</i> = 267) patients presented with a painless swelling involving the mandible. Follicular pattern was the most predominant histopathological pattern 44.87% (<i>n</i> = 175) followed by plexiform pattern, accounted for 32.82% (<i>n</i> = 128) but in the recurrent cases, there was a relatively higher number of plexiform patterns 11.54% (<i>n</i> = 45), unlike other histopathological patterns. Patients that had recurrence, only 1.28% (<i>n</i> = 5) were treated by radical surgery compared to 23.32% (<i>n</i> = 91) who underwent conservative surgery.</p> Conclusion <p>This investigation reports a reasonably significant rate of recurrence in approximately a quarter 24.62% (<i>n</i> = 96) of the study patients. This is the largest histopathological study regarding ameloblastoma management from Sudan, and our results recommending radical surgery for the treatment of tumours.</p>

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Gross histopathological features and treatment outcomes of ameloblastoma at Khartoum teaching dental hospital: A retrospective cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月19日

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  • Saba Eltayeb Mohammed Ahmed,
  • Nourelhoda Alim,
  • Fatema Akhter,
  • Tahsinul Haque,
  • Mohamed Abdelwahab Higzi,
  • Raghad Abdullah Altassan,
  • Aseel Tariq Aboaljadayel,
  • Mohammed Saad Alqarni,
  • Sally Elhaddad,
  • Tasnia Habib,
  • Turki Thaar AlQahtani,
  • Nuha Abdalla Osman Mustafa,
  • Abdullah Alanazi

摘要

Aim

The aim of this study is to interrogate the gross histopathological patterns, correlation between histological type with tumor location, treatment, and complications of patients with ameloblastomas seen at Khartoum Teaching Dental Hospital.

Method

This was a cross-sectional retrospective laboratory-based study using 390 patients identified histologically with ameloblastoma between the years 2010–2017. Information regarding age, gender, histopathologic type, anatomical site, tumour size, clinical and radiographic data as well as biological features of the types of ameloblastoma was obtained from laboratory demand outlines. Categorical and continuous variables were summarized in percentage and mean ± standard deviation, respectively. Continuous and categorical variables were summarized using mean ± standard deviation (SD) and percentages, respectively. Sociodemographic characteristics and healthcare-related variables were compared using the chi-square test, while economic status was analyzed using Duncan’s multiple range test.

Results

A total of 390 patients of ameloblastoma were included with a mean patient age of 30.74 ± 5.21 years (range: 9–68 years), male to female ratio of patients was 1.3:1. Maximum of approximately 68.46% (n = 267) patients presented with a painless swelling involving the mandible. Follicular pattern was the most predominant histopathological pattern 44.87% (n = 175) followed by plexiform pattern, accounted for 32.82% (n = 128) but in the recurrent cases, there was a relatively higher number of plexiform patterns 11.54% (n = 45), unlike other histopathological patterns. Patients that had recurrence, only 1.28% (n = 5) were treated by radical surgery compared to 23.32% (n = 91) who underwent conservative surgery.

Conclusion

This investigation reports a reasonably significant rate of recurrence in approximately a quarter 24.62% (n = 96) of the study patients. This is the largest histopathological study regarding ameloblastoma management from Sudan, and our results recommending radical surgery for the treatment of tumours.