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Objective <p>The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index/albumin ratio (SII/ALB) for predicting immunotherapy prognosis and efficacy in Non-small cell lung carcinoma (NSCLC) treated with Immune checkpoint inhibitors (ICIs) and opioids.</p> Methods <p>A total of 78 NSCLC patients received ICIs and opioids were retrospectively collected. The optimal cut-off values were determined by receiver operating characteristic curves. The univariate and multivariate analysis investigated the effects of NLR, PLR, and SII/ALB on patients prognosis.</p> Results <p>NLR and PLR had predictive value of efficacy. SII/ALB &gt; 17.79 was an independent risk factor for worse outcomes.</p> Conclusion <p>PLR and SII/ALB have predictive value of efficacy, but NLR was not. SII/ALB &gt; 17.79 suggests a poor prognosis following immunotherapy in NSCLC patients receiving ICIs and opioids.</p>

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Peripheral blood inflammatory biomarkers neutrophil/ lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index/albumin ratio predict prognosis and efficacy in non-small cell lung cancer patients receiving immunotherapy and opioids

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月10日

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  • Yan Lei,
  • Chengsong Cao,
  • Rui Tang,
  • Yong Liu

摘要

Objective

The study aimed to assess the value of pretreatment peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immune-inflammation index/albumin ratio (SII/ALB) for predicting immunotherapy prognosis and efficacy in Non-small cell lung carcinoma (NSCLC) treated with Immune checkpoint inhibitors (ICIs) and opioids.

Methods

A total of 78 NSCLC patients received ICIs and opioids were retrospectively collected. The optimal cut-off values were determined by receiver operating characteristic curves. The univariate and multivariate analysis investigated the effects of NLR, PLR, and SII/ALB on patients prognosis.

Results

NLR and PLR had predictive value of efficacy. SII/ALB > 17.79 was an independent risk factor for worse outcomes.

Conclusion

PLR and SII/ALB have predictive value of efficacy, but NLR was not. SII/ALB > 17.79 suggests a poor prognosis following immunotherapy in NSCLC patients receiving ICIs and opioids.